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Methylprednisolone

QuestionAnswer
GENERIC NAME Methylprednisolone
BRAND NAME Solu-Medrol
CLASS Anti-inflammatory Glucocorticoid
MECHANISM OF ACTION Synthetic corticosteroid that suppresses acute and chronic inflammation; Potentiates vascular smooth muscle relaxation by beta-adrenergic agonist.
INDICATIONS Acute spinal cord trauma, anaphylaxis, bronchodilator for unresponsive asthma.
CONTRAINDICATIONS Premature infants, systemic fungal infections, Use with caution in patients with GI bleeding.
ADVERSE REACTIONS HA, HTN, Sodium and water retention, CHF, Hypokalemia, alkalosis, peptic ulcer disease, N/V
NOTES ON ADMINISTRATION Pregnancy safety not established, crosses the placenta and may cause fetal harm. Not effective if spinal cord injury is greater then 8 hours.
INCOMPATABILITIES/DRUG INTERACTIONS Hypoglycemic responses to insulin and hypoglycemic agents may be blunted. Potassium-depleting agents may exacerbate hypokalemic effects.
DOSE/ROUTE Adult Acute spinal cord injury 30mg/kg IV over 30 minutes followed by an infusion.
DOSE/ROUTE Adult asthma and COPD 1-2mg/kg IV.
DOSE/ROUTE Pediatric Same as adult
ONSET OF ACTION 1-2 hours
PEAK EFFECTS Variable
DURATION OF ACTION 8-24 hours
AZ DRUG BOX SUPPLY RANGE 250mg
Created by: klindley