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DNA & Protein Vocab
DNA replication & Protein Synthesis Vocabulary
Term | Definition |
---|---|
purines | A;G; two rings |
pyrimidines | T;C;U; one ring |
Griffith | Mice experiment proved bacteria could get traits from other bacteria by transforming their traits. |
Avery, McCarty & MacLeod | Proved transforming agent was nucleic acid. |
Hershey & Chase | "Blender Experiment" with bacteriophages; proved DNA is hereditary material |
Wilkins & Franklin | used x-ray crystallography; produced a picture of DNA |
Watson & Crick | used Wilkins & Franklin's picture to create model; showed double helix and base pairs |
Ribosomal RNA | major component of ribosomes |
Transfer RNA | folded upon itself; carries the amino acids to the mRNA (ribosome where it is located) |
Messenger RNA | sequence of nucleotides that determines the primary sequence of the polypeptide; made in the nucleus from the DNA; transcription |
snRNA | forms the "splicesomes" - which are used to cut out intons from pre-mRNA |
siRNA (small-interferring) | targets specific mRNA and prohibits it from being expressed |
activator | bind to regulatory switches in a sequence-specific manner |
mediators | bring bound activators in contact with proteins bound to the promoter |
DNa polymerase | helps make the new matching DNA strand by adding nucleotides one at a time and joining each new nucleotide the the previous nucleotide int he growing DNA strand. |
helicase | unwinds parental double helix at replication forks |
single-strand binding protein | binds to an stabilizes single-stranded DNA until it is used as a template |
topoisomerase | relieves overwinding strain ahead of replication forks by breaking, swiveling, and rejoining DNA strands |
primase | synthesizes an RNA primer at 5' end of leading strand and at 5' end of each Okazaki fragment of lagging strand |
DNA pol III | Using parental DNA as a template, synthesizes new DNA strand by adding nucleotides to an RNA primer or a pre-existing DNA strand |
DNA pol I | REmoves RNA nucleotides of primer from 5' end and replaces them with DNA nucleotides |
DNA ligase | Joins Okazaki fragments of lagging strand; on leading strand, joins 3' end of DNA that replaces primer to rest of leading strand DNA |
A site | holds tRNA carrying next amino acid to be added to chain |
P site | holds tRNA carrying growing polypeptide chain |
E site | Empty tRNA leaves ribosome from exit site |
missense | change amino acid to amino acid |
nonsense | change from amino acid to stop codon |
RNA primer | formed from RNA nucleotide bonds to start strand |
RNA polymerase | lays down the nucleotides 5' to 3' direction |
central dogma | flow of genetic information in a cell |
promoter region | biding site before beginning of a gene; TATA box; binding site for RNA polymerase & transcription factors |
enhancer region | binding site far upsream of gene; speeds up process |
transcription factors | turn on or off transctipion; triggers the binding of RNA polymerase to DNA; bind to promoter region of DNA |
initiation | tRNA carrying an amino acid comes in P-stie and bonds by base pairing its ancitcodon witht the mRNA start codon |
Elongation | the second tRNA then comes into A-site and bods to codon of mRNA |
termination | ribosome continues reading mRNA untial a stop codon is reached |
nucleosomes | histone proteins |