click below
click below
Normal Size Small Size show me how
ANEMIA
| Question | Answer |
|---|---|
| Types of Anemia | Microcytic, Normocytic, Macrocytic |
| Microcytic Anemia | Mean cell volume is lower than normal. Iron deficiency, hemoglobinopathy, chronic disease, lead disease. |
| Normocytic Anemia | Mean cell volume is normal. Acute bleeding, aplastic, hemolytic, low erythropoietin, malignancy. |
| Macrocytic Anemia | Low vitamin B12, low folate. |
| Anemia vs. Polycythemia | Anemia = deficit of RBCs |
| Vitamin B12 | essential for synthesis of DNA; without B12 cells cannot divide properly |
| Folate | necessary for synthesis of nucleic acids and nuclear maturation of RBCs; involved with DNA replication |
| Iron | essential to hemoglobin. iron is what carries the oxygen in the RBC. |
| Stem Cells | RBCs are developed from stem cells |
| Erythropoietin | kidney hormone that synthesizes RBCs; action on stem cells turns them into mature RBCs |
| Hemoglobin in Mature RBCs | in each mature RBC = 300 hemoglobin molecules. compromise 90% of dry weight |
| Hemoglobin Catabolism | Hemoglobin is broken into globin and heme (biliverdin). Biliverdin is broken into bilirubin which is then broken into bile and iron. Both globin and iron are recylced. |
| General Signs of Anemia | increased respiration, increased HR, fatigue, decreased activity, pallor, transient heart murmor |