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General 3

Q bank: Randomly Generated 3

Alternating constricion and dilation of intrahepatic bile ducts in a UC patient causing jaundice. Primary sclerosing cholangitis; associated with UC
What is the virus associated with nasopharyngeal carcinoma? EBV; also malignant soft-tissue mass of the jaw
What virus is associated with adult T-cell leukemia? Human T-lymphocyte virus (HTLV-1)
What virus is associated with cutaneous and mucous-membrane plaque-like violaceous lesions? Kaposi sarcoma, associated with HHV 8
This drug prevents the binding of aminoacyl-tRNA to ribosomes. Tetracycline
This type of amyloid is seen in primary amyloidosis and most frequently deposits in the heart. Transthyretin
This type of amyloid is associated with secondary amyloidosis (autoimmune, chronic infection) and deposition occurs mostly in kidney, spleen and liver. Amyloid-associated protein
This type of amyloid is seen in primary amyloidosis with systemic deposition. Amyloid light chain
This type of amyloid is seen with long-term hemodialysis with musculoskeletal deposition. Beta-2 microglobulin
7 yro girl develops behavior changes, and school perforrmance detiorates. Months later develops seizures, ataxia, and focal neurologic symptoms. Eventually quadriparetic, spastic, and unresponsive. Death within a year. What virus at age 1 caused this? Rubeola; patient has subacute sclerosing panencephalitis
What type of hypersensitivity reaction is the tuberculin skin test? Delayed-type (type IV) cell mediated immune response involving CD4 TH1 activation of macrophages
What type of hypersensitivity is an Arthus reaction? Immune complex (type III) involving antibody, antigen, and complement activation
60 yro man presents with bacterial meningitis, what are the most likely agents? S pneumoniae, Listeria, N meningitidis
What test is used to distinguish between heretiable and sporadic retinoblastoma? PCR; in heritable cases, any cell in the body will show altered chromosome (deletion or translocation), in sporadic caases only the tumor will show mutation
Patient has CN function with the exception of the ability to look up. Diagnosis? Pinealoma; compresses vertical gaze center in the tectum of the midbrain
Where are the estrogen, progesterone, and HER2 EGF receptors located? Estrogen and progesterone are located in the nucleus, HER-2, a growth factor, likely has it's receptor on the cell membrane
What stain is used to identify hairy cell leukemia? tartrate-resistant acid phosphatase (TRAP)
Bilateral bruits of the renal arteries with a beaded pattern on angiography. If these vessels were surgically resect, what would be apparent? Fibromuscular dysplasia
The median nerve is subject to entrapment neuropathy when it passes between the two heads of what muscle? Pronator teres
What causes the sensation of pain felt in carpal tunnel syndrome? Compression of the median nerve
What is angiostatin? anti-angiogenic factor expressed by tumors that tends to inhibit angiogenesis
What would be the difference in the appearance of chromatin of prostatic cells in castration versus trauma to the prostate? Castration (removal of androgenic stimuli) induces apoptosis in prostate cells. Chromatin would exhibit peripheral aggregation; Trauma would cause chromatin to become more pale (karyolysis) and form irregular clumps
65 yro man with ankle edema, and inflammation of the skin near both ankles. Skin exhibits edema, mild scaling, and brown discoloration. On one ankle, a 1 cm ulcerated area seen in erythematous area. Diagnosis? Stasis dermatitis from venous stasis
These viruses are segmented, and thus are capable of genetic drift. Influenzae of orthomyxoviridae; Rotavirus and Reovirus of reoviridae; Ortho is single stranded, reo is double stranded (the only RNA viral family that is)
These cells in the semineferous tubule have very pale nucleus and darkly staining nucleoli. Sertoli cells, establish blood-testis barrier via tight junctions (note they do not protect the spermatogonia which lie directly on BM)
What are the tumors related to von-Hippel Lindau disease and what chromosome is the deletion on? Hemangioblastomas of the retina, cerebellum, and/or medulla. Roughly half will develop bilateral renal-cell carcinoma; VHL gene deletion on chromosome 3
A patient with truncus arteriosus will also have what cardiac abnormality? VSD
This is a mesenteric membrane between the liver and the anterior abdominal wall. Falciform ligament
Chronic poisoning with this substance causes CNS atrophy, gingivitis, gastritis, and renal tubular changes. Chronic mercury poisoning
This drug causes both metabolic acidosis and respiratory alkalosis. Salicylates
Patients with myasthenia gravis have autoantibodies directed against what cellular component? Nicotinic acetylcholine receptors at motor endplates (ligand gated ion channels)
Patients with Lamber-Eaton syndrome have autoantibodies directed against what cellular components? voltage-gated calcium channels
Proliferative synovitis with many lymphocytes, macrophages, and plasma cells. Diagnosis? Rheumatoid arthritis
Joints with excessive cartilage loss and reactive bone formation. Osteoarthritis
This macrolide inhibits calcineurin-mediated transcription of IL-2, and is used to prevent cytotoxic T cell activation in liver transplant patients with adverse corticosteroid reactions. Tacrolimus
This drug used in renal transplanation inhibits T-cell proliferation by binding serine threonine kinase (mTOR) necessary for cell-cycle progression. Sirolimus
This type of leukemia is related to DIC upon implementation of antineoplastic agents. Promyelocytic (M3) AML; release of Auer rod granules triggers DIC
What nerves are responsible for adduction and extension of the thumb? Ulnar nerve (adductor pollicis); Radial nerve (extensor pollicis longus and brevis)
Malignant mesenchymal tumor that develops in the pelvis, shoulders, or ribs which appears slightly basophilic on H&E. Chondrosarcoma
Benign bone-forming tumor composed of well-differentiated bone trabeculae arranged haphazardly. Osteoid osteoma or osteoblastoma (larger and found in vertebrae)
Rhabdomyoma are related to what disorder? Tuberous sclerosis
Imagined bodily defect or exaggerated distortion of minimal or minor defect with impairment of social, occupational, or other are of functioning. Diagnosis? Body dysmorphic disorder
Unconscious drive for medical attention, often accompanying somatoform pain disorder. Secondary gain; somatoform pain is pain unsupported by any physiologic process
Created by: rahjohnson



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