Help
Options
Didn't know it?
click below
click below
Knew it?
click below
click below
Don't Know
Remaining cards (0)
Know
retry
shuffle
restart
0:00
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.
Normal Size Small Size show me how
Normal Size Small Size show me how
Heme-Onc 1
First Aid Q&A: Hematology & Oncology 1
| Question | Answer |
|---|---|
| The best prognostic indicator of melanoma | Depth of invastion into dermis (vertical growth) |
| 43 yro male with epigastric pain, heartburn, weight loss for 4 months; few occasions of black, tarry stools; diffuse epigastric pain. Diagnosis? | Zollinger-Ellison |
| Pancoast's tumor impinging on cervical sympathetic plexus. What is the syndrome and it's symptoms? | Horner's syndrome: ptosis, miosis, anhidrosis |
| Risk factors for breast cancer | Family history, delayed menopause (>50), early menarche (<12), late pregnancy (>30), old age |
| Site of action: heparin vs. low molecular weight heparin | Heparin works on antithrombin III and Xa, whereas LMW heparin works predominantly on Xa |
| Warfarin blocks activation of what processes? | Vitamin K dependent processes (II, VII, IX, and X) |
| Brain tumor predominantly in children found exclusively in cerebellum | Medulloblastoma |
| Most common brain tumor of adults; found in the cerebral hemispheres. Grave prognosis (almost zero survival at 5 years) | Glioblastoma multiforme |
| Benign tumor found in frontal lobes, classically described as consisting of "fried egg" cells | Oligodendroglioma |
| Most common supratentorial tumor in children, derived from remnants of Rathke's pouch | Craniopharyngioma |
| Nonmalignat neoplasm arising from arachnoid granulations | Meningioma |
| Lack of uroporphyrinogen I synthetase. Symptoms result from buildup of delta-ALA and porphobilinogen | Acute intermitten porphyria; symptoms 4 P's (painful abdomen, pink urine, polyneuropathy, psychological disturbances) |
| Most common form of thyroid cancer, often associated with ionizing radiation exposure. | Papillary carcinoma, excellent prognosis |
| Thyroid histology reveals branching papillae lined by epithelial cells with ground glass nuclei "Orphan Annie eye nuclei" and concentrically calcified psammoma bodies. | Papillary carcinoma |
| Thyroid histology reveals uniform cells surrounding colloid-filled follicles with Hurthle cells; no psammoma bodies | Follicular carcinoma; second most common thyroid cancer |
| Neoplasm of parafollicular or C cells of thyroid resulting in increased serum calcitonin. | Medullary carcinoma; may be associated with MEN II when bilateral |
| Congenital abnormality caused by persistance of diverticulum formed during thyroid gland migration | Thyroglossal cyst |
| Deficiency in Hemophilia A | Factor VIII; X linked |
| Deficiency in Hemophilia B | Factor IX; X linked |
| Multiple micro-infarcts in spleen result in functional asplenia, patients are thus susceptible to encapsulated bacterium. Diagnosis? | Sickle cell anemia |
| Sickle cell patients are at risk of having an aplastic crises often associated with what infection? | B19 parvovirus |
| Splenomegaly and fatigue with Auer rod cytoplasmic inclusions on peripheral blood smear. Diagnosis? | AML |
| Splenomegaly and fatigue with teardrop-shaped RBC's on peripheral blood smear. Diagnosis? | Chronic idiopathic myelofibrosis |
| Splenomegaly and fatigue with B cells showing filamentous projections | Hairy cell leukemia |
| Common site of metastasis for GI tumors | Liver (portal blood flow) |
| Common site of metastasis for breast, kidney, and lung tumors | Most often brain and bone |
| What is the mechanism of lead poisening resulting in anemia? | Lead inhibits ALA dehydratase and ferrochetalase preventing porphobilinogen formation and iron incorporation |
| Familial adenomatous polyposis results from mutation of what chromosome? | Chromosome 5 |
| What abnormal labs are expected with cobalamin deficiency? | Increased mean corpuscular volume and mean corpuscular hemoglobin, and elevated and methylmalonic acid |
| What disorders are associated with MEN IIA and what oncogene is distinct? | Parathyroid hyperplasia or tumor, medullary carcinoma, and pheochromocytoma; Ret oncogene |
| What disorders are associated with MEN I? | Wermer's syndrome effects 3 P's: pituitary, parathyroid, pancreas |
| Parasitic infection presenting with hepatomegaly, splenomegaly, anemia, malaise and weight common to middle east locations | Leishmania donovani |
| Parasitic infection presenting with bloating, flatulence, and foul smelling diarrhea. | Giardia lamblia |
| parasitic infection with 48 hour cyclic fever, can remain dormant in the liver for long periods of time | Plasmodium ovale |
| Where does intrinsic factor bind B12 and later receptors? | IF binds B12 in small intestine (not stomach) and receptors in distal ileum (ileal resection can result in B12 deficiency) |
| Function of transcobalamin II | binds B12 in ileal cells for transport through bloodstream |
| Tumor arising from embryonic renal cells from the embryonic kidney. Most common solid tumor of childhood (most occurring between 2-4 years) | Wilm's tumor |
| Tumor derived from renal tubular cells commonly in male smokers age 50 to 70 years. | Clear cell carcinoma of the kidney |
| Most common tumor of the urinary tract, usually presenting with painless hematuria and urinary outflow obstruction | Transitional cell carcinoma |
| Complement mediated RBC lysis due to insufficient synthesis of GPI anchors. Dark urine in the morning. | Paroxysmal nocturnal hemoglobinuria |
| Deficiency of vWF metalloprotease resulting in microangiopathic hemolytic anemia with schistocytes on peripheral blood smear. | Thrombotic thrombocytopenic purpura (TTP) |
Created by:
rahjohnson
Popular USMLE sets