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First Aid Neo Pharm

Anti-neoplastics

QuestionAnswer
Folic acid analog that inhibits dihydrofolate reductase Methotrexate
Pyrimidine analog that inhibits thymidylate synthase 5-fluorouracil
Inhibitor of de novo purine synthesis 6-mercaptopurine
Inhibits DNA polymerase cytarabine
Alkylating agents used to treat Non-Hodgkin lymphoma, breast and ovarian carcinoma. Notable side effect of hemorrhagic cystitis Cyclophosphamide, ifosfamide
Alkylating agent capable of crossing blood brain barrier Nitrosureas (carmustine, lomustine)
Similar to alkylating agent, notable toxicities include nephrotoxicity and acoustic nerve damage Cisplatin, carboplatin
Alkylating agent used to treat CML Busulfan
Free radical generator and also intercalates DNA to from strand breaks ("A" in ABVD treatment for Hodgkins) Doxorubicin (Adriamycin), daunorubicin
Used to treat childhood tumors (Wilm's tumor, rhabdomyosarcoma, and Ewing's sarcoma) Dactinomycin (Actinomycin D; Children ACT out)
Free radical generator which can cause life threatening pulmonary fibrosis Bleomycin
Topoisomerase II inhibitor Etoposide
Steroid that triggers apoptosis Prednisone
Estrogen receptor antagonist Tamoxifen
Monoclonal antibody against HER-2 Trastuzumab
Philadelphia chromosome bcr-abl tyrosine kinase inhibitor Imatinib (Gleevec)
Binds tubulin blocking polymerization of microtubules and mitotic spindle formation Vincristine, vinblastine
Binds tubulin hyperstabalizing microtubules and blocking mitotic spindle formation Paclitaxel
Toxicity includes Cushing-like symptoms Prednisone
Used for "metastatic" breast cancer Trastuzumab
Increased risk of endometrial carcinoma Tamoxifen
Do not use with allopurinol 6-mercaptopurine (activated by xanthine oxidase; allopurinol is a xanthine oxidase inhibitor used to treat gout)
CNS toxicity Nitrosureas (carmustine, lomustine
Reversible myelosuppression with leucovorin rescue Methotrexate
Neurotoxic (areflexia, peripheral neuritis) paralytic ileus Vincristine (Vinblastine is notable for bone marrow suppression)
Antineoplastic used for therapeutic abortion Methotrexate
Androgen receptor antagonist Flutamide
Recombinantly produced cytokine used to treat hairy cell leukemia Interferon alpha
GnRH agonist used for the treatment of metastatic prostate carcinoma Leuprolide, Goserelin, Nafarelin
Monoclonal antibody used for treatment of low grade non-Hodgkin lymphoma Rituximab
Aromatase inhibitor used to treat breast cancer Anastrozole
Created by: rahjohnson
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