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DU PA Bhv Hlth Pharm
Duke PA Behavioral Health Pharmacology
| Question | Answer |
|---|---|
| most clinically useful antidepressant drugs potentiate, either directly or indirectly the actions of _______ in the brain | norepinephrine and or serotonin |
| Selective Serotonin Reuptake Inhibitor | Citalopram |
| Selective Serotonin Reuptake Inhibitor | Escitalopram |
| Selective Serotonin Reuptake Inhibitor | Fluoxetine |
| Selective Serotonin Reuptake Inhibitor | Fluvoxamine |
| Selective Serotonin Reuptake Inhibitor | Paroxetine |
| Selective Serotonin Reuptake Inhibitor | Sertaline |
| Serotonin/Norepinephrine re-uptake Inhibitors | Duloxetine |
| Serotonin/Norepinephrine re-uptake Inhibitors | Venlafaxine |
| Atypical Antidepressants | Bupropion |
| Atypical Antidepressants | Mirtazapine |
| Atypical Antidepressants | Nefazodone |
| Tricyclic Antidepressants | Trazodone |
| Tricyclic Antidepressants | Amitriptyline |
| Tricyclic Antidepressants | Clomipramine |
| Tricyclic Antidepressants | Desipramine |
| Tricyclic Antidepressants | Doxepin |
| Tricyclic Antidepressants | Imipramine |
| Tricyclic Antidepressants | Maprotiline |
| Tricyclic Antidepressants | Nortriptyline |
| Tricyclic Antidepressants | Protriptyline |
| Tricyclic Antidepressants | Trimipramine |
| Monoamine Oxidase Inhibitors | Phenelzine |
| Monoamine Oxidase Inhibitors | Selegiline |
| Monoamine Oxidase Inhibitors | Tranylcypromine |
| Drugs used to treat mania and Bipolar disorder | Carbamazepine |
| Drugs used to treat mania and Bipolar disorder | Lithium salts |
| Drugs used to treat mania and Bipolar disorder | Valproic acid |
| Selective Serotonin Reuptake Inhibitor | Have little blocking activity at muscarinic, alpha-adrenergic, and histaminic H1 receptors |
| Selective Serotonin Reuptake Inhibitor | have largely replaced tricyclic antidepressants and monoamine oxidase inhibitors as DOC in treatment of depression |
| antidepressants take ____ weeks to show a significant improvement in mood | 2 |
| Selective Serotonin Reuptake Inhibitor | about 1/50 adolescents become more suicidal as a result of treatment with this antidepressant |
| Selective Serotonin Reuptake Inhibitor | has a lower adverse effect profile compared to other antidepressants |
| The SSRI with the lowest risk of causing an SSRI discontinuation syndrome | Fluoxetine |
| sometimes effective in relieving neuropathic pain such as diabetic peripheral neuropathy | SNRI's and tricyclics |
| not recommended in patients with end stage renal disease | Duloxetine |
| should not be administered in patients with hepatic insufficiency | Duloxetine |
| is unique in that it assists in decreasing the craving and attenuating the withdrawal symptoms for nicotine | Bupropion |
| Is markedly sedating due to its antihistaminic activity, can also cause increased appatite and weight gain | Mirtazapine |
| has been associated with causing priapism | Trazodone |
| Uncommon side effects for SSRI's | orthostatic hypotension, sedation, dry mouth, and blurred vision |
| TCAs are effective in treating moderate to severe depression. Some patients with ____ also respond to TCAs | panic disorder |
| The TCA Imipramine has been used to control | bed wetting in children |
| The TCA Amitriptyline has been used to treat | migraines |
| Blockade of muscarinic receptors leads to | blurred vision, xerostomia, urinary retention, constipation, and aggravation of narrow angel glaucoma |
| Blockade of alpha-adrenergic receptors leads to | orthostatic hypotension, dizziness, and reflex tachycardia |
| common AE of TCA | weight gain |
| Occurs in a significant minority of patients on TCA's as compared to SSRI's | sexual disfunction |
| TCA's should be used with caution in known manic depressives because they may | cause manic behavior |
| Depressed patients should only be given limited quantities of TCA's because | of their narrow therapuetic window |
| MAOI's have a ____ effect | amphetamine like stimulant |
| MAOI's are idicated for | patients allergic/unresponsive to TCA's |
| TCA's are an important alternative to | SSRI's |
| This limits the widespread use of MAOI's | unpredictable side effects due to food and drug interactions |
| Considered a mood stabilizer, it is not a sedative, euphoriant, or depressant | Lithium salts |