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DU PA Bhv Hlth Pharm
Duke PA Behavioral Health Pharmacology
Question | Answer |
---|---|
most clinically useful antidepressant drugs potentiate, either directly or indirectly the actions of _______ in the brain | norepinephrine and or serotonin |
Selective Serotonin Reuptake Inhibitor | Citalopram |
Selective Serotonin Reuptake Inhibitor | Escitalopram |
Selective Serotonin Reuptake Inhibitor | Fluoxetine |
Selective Serotonin Reuptake Inhibitor | Fluvoxamine |
Selective Serotonin Reuptake Inhibitor | Paroxetine |
Selective Serotonin Reuptake Inhibitor | Sertaline |
Serotonin/Norepinephrine re-uptake Inhibitors | Duloxetine |
Serotonin/Norepinephrine re-uptake Inhibitors | Venlafaxine |
Atypical Antidepressants | Bupropion |
Atypical Antidepressants | Mirtazapine |
Atypical Antidepressants | Nefazodone |
Tricyclic Antidepressants | Trazodone |
Tricyclic Antidepressants | Amitriptyline |
Tricyclic Antidepressants | Clomipramine |
Tricyclic Antidepressants | Desipramine |
Tricyclic Antidepressants | Doxepin |
Tricyclic Antidepressants | Imipramine |
Tricyclic Antidepressants | Maprotiline |
Tricyclic Antidepressants | Nortriptyline |
Tricyclic Antidepressants | Protriptyline |
Tricyclic Antidepressants | Trimipramine |
Monoamine Oxidase Inhibitors | Phenelzine |
Monoamine Oxidase Inhibitors | Selegiline |
Monoamine Oxidase Inhibitors | Tranylcypromine |
Drugs used to treat mania and Bipolar disorder | Carbamazepine |
Drugs used to treat mania and Bipolar disorder | Lithium salts |
Drugs used to treat mania and Bipolar disorder | Valproic acid |
Selective Serotonin Reuptake Inhibitor | Have little blocking activity at muscarinic, alpha-adrenergic, and histaminic H1 receptors |
Selective Serotonin Reuptake Inhibitor | have largely replaced tricyclic antidepressants and monoamine oxidase inhibitors as DOC in treatment of depression |
antidepressants take ____ weeks to show a significant improvement in mood | 2 |
Selective Serotonin Reuptake Inhibitor | about 1/50 adolescents become more suicidal as a result of treatment with this antidepressant |
Selective Serotonin Reuptake Inhibitor | has a lower adverse effect profile compared to other antidepressants |
The SSRI with the lowest risk of causing an SSRI discontinuation syndrome | Fluoxetine |
sometimes effective in relieving neuropathic pain such as diabetic peripheral neuropathy | SNRI's and tricyclics |
not recommended in patients with end stage renal disease | Duloxetine |
should not be administered in patients with hepatic insufficiency | Duloxetine |
is unique in that it assists in decreasing the craving and attenuating the withdrawal symptoms for nicotine | Bupropion |
Is markedly sedating due to its antihistaminic activity, can also cause increased appatite and weight gain | Mirtazapine |
has been associated with causing priapism | Trazodone |
Uncommon side effects for SSRI's | orthostatic hypotension, sedation, dry mouth, and blurred vision |
TCAs are effective in treating moderate to severe depression. Some patients with ____ also respond to TCAs | panic disorder |
The TCA Imipramine has been used to control | bed wetting in children |
The TCA Amitriptyline has been used to treat | migraines |
Blockade of muscarinic receptors leads to | blurred vision, xerostomia, urinary retention, constipation, and aggravation of narrow angel glaucoma |
Blockade of alpha-adrenergic receptors leads to | orthostatic hypotension, dizziness, and reflex tachycardia |
common AE of TCA | weight gain |
Occurs in a significant minority of patients on TCA's as compared to SSRI's | sexual disfunction |
TCA's should be used with caution in known manic depressives because they may | cause manic behavior |
Depressed patients should only be given limited quantities of TCA's because | of their narrow therapuetic window |
MAOI's have a ____ effect | amphetamine like stimulant |
MAOI's are idicated for | patients allergic/unresponsive to TCA's |
TCA's are an important alternative to | SSRI's |
This limits the widespread use of MAOI's | unpredictable side effects due to food and drug interactions |
Considered a mood stabilizer, it is not a sedative, euphoriant, or depressant | Lithium salts |