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Blood NRTC
Chapter 13
Question | Answer |
---|---|
What is the pigment that gives blood it's red color | Hemoglobin |
What blood cell transports oxygen | RBC- Red Blood Cell |
What gives the RBC it's ability to transport oxygen and Iron | It's disk shape... Because it contains a small dip in the middle that's great for diffusion of the molecules into it. |
What is the name of the disease characterized by a sickle shaped RBC | Sickle cell anemia |
Why does the sickle shaped RBC cause anemia | It doesn't transport Iron well |
Why is sickle cell more prevalent in African Americans | It is genetic ( it requires the trait from both parents to be passed down to have offspring be affected by it) |
What are the 4 ribbon-like protein chains found in hemoglobin called | Globins |
What is the molecule, that contains iron, which binds to globin | Heme |
How does hemoglobin bind and carry oxygen | One oxygen molecule binds to each heme( there are 4 hemes in each hemoglobin) |
What is the study of blood | Hematology |
What is a hematocrit | Measure of RBC - and concentration of hemoglobin |
Is blood bright red or deep maroon when it is oxygenated | Bright red |
What molecule is crucial for the production of hemoglobin | Iron |
About how long does the RBC live | 120 days |
The way the negative feedback loop is triggered | Oxygen levels fall |
When the kidneys detect low oxygen they respond by secreting what hormone | Erythropoietin ( EPO) |
What does EPO stimulate | Bonne marrow |
When stimulated by EPO what does the marrow do | Begins the process of making new erythrocytes |
Name of an immature erythrocyte | Reticulocyte |
How many days does it take for a erythrocyte to mature | One or two days |
After the Erythrocyte is mature it causes the oxygen level in circulation to do what | Increase |
What happens when the O2 levels rise | Kidneys stop secreting EPO and RBC production decreases |
Erythropoiesis is what process | Producing new erythrocytes |
Moving to higher altitude can do what to RBC count | Increase the count |
How many days does it take for the process of erythropoiesis | 3-5 days |
As the aged RBC passes threw the spleen what happens to it | It begins to break down |
What are two organs involved in breakdown of old RBC | Liver and spleen |
What is hemoglobin broken down into | Globin and heme |
What is globin broken down into | Amino acids... That are later used for energy |
What 2 things does heme break down into | Iron and bilirubin |
Where are the iron molecules transported to when a RBC is broken down | To the Marrow to be used to create new hemoglobin |
When heme is broken down... What happens to the bilirubin it contained | It is excreted into the intestines as part of bile |
What is a buildup of bilirubin | Jaundice |
Jaundice can result from a buildup of bilirubin and what other complication or disfunction | Liver problem |
Polycemia is | Too many RBC circulating |
What is a big risk with polycemia | Thick blood could lead to clots... Cells die... Possible necrosis= lots of pain |
What is a CBC | Complete blood count... RBC WBC And platelet count |
What is a CBC with differentiation | It if a CBC plus amount of Kinds of WBC you have... Helps Dr. diagnose disease |
Abnormal liver function can interfere with.... | Blood clotting |
To stop bleeding more quickly, from a wound, you can massage ... | The tissues surrounding the wound. |
Whats the next thing that happens after a blood clot forms in a wound? | The platelets contract, pulling the edges of the damaged vessel closer together. |
After a damaged vessel has healed what process happens next? | Fibrinolysis |
Process in which plasmin works to dissolve the fibrin meshwork, and the blood clots break up? | Fibrinolysis |
The inner lining of undamaged blood vessels that are very smooth | Smooth endothelium |
Smooth endothelium is very smooth to reduce... | Friction |
How does smooth endothelium help prevent blood clots? | Helps prevent platelets from sticking and reduces friction |
The blood normally produces small amounts of ... | Thrombin |
When blood is circulating normally, the rapidly moving blood stream prevents blood clots by.... | Diluting the thrombin before a clot can form |
If thrombin has accumulated to the point that a blood clot has developed, what can cause this? | When blood flow has decreased |
Prolonged sitting or lying can cause blood flow to... | decrease |
Basophils and mast cells normally secrete which anticoagulant? | Heparin |
Which anticoagulant prevents blood clots by blocking the action of thrombin? | Heparin |
Exercise can help normal... | blood flow |
Normal blood flow is NOT.... | Stagnant or stationary |
The surface of each RBC carries a protein called.. | Antigen (also called agglutinogen) |
People with type A blood have Which antigen/s on their RBC's? | A antigen |
People with type B blood have which antigen/s on their RBC's? | B antigen |
People with type AB blood have which antigen/s on their RBC's? | Both A and B antigens |
People with type O blood (have/don't have) antigen/s on their RBC's. | Don't have antigens |
Type A RBC's have which antibodies? | has B antibodies |
Type B RBC's have which antibodies? | has A antibodies |
Type O RBC's have which antibodies? | has A and B antibodies |
The rarest blood type is.. | Type AB |
Which blood type is a universal recipient? | Type AB |
Type AB RBC's have which antibodies? | They do not have antibodies |
Antibodies are carried by the .. | blood plasma |
Carries antigens | the blood cell |
During a transfusion, if a recipients plasma contains antibodies against the ABO type being used, these antibodies will attack the donor's RBC's causing a ... | transfusion reaction |
Signs and symptoms of a transfusion reaction | difficulty breathing, flank pain, feelings of impending doom, temperature spike |
First thing you should do when you suspect a tranfusion reaction? | Stop the pump |
When RBC's clump together, it means that they .. | agglutinate |
Clumping of RBC's blocks the.. | blood vessels |
At birth, ABO antibodies are.. | not present |
Most common blood type | Type O |
During a transfusion: when a person with Rh-negative blood recieves Rh-positive blooed, their body see's the Rh antigen as.. | something foreign |
IF a person with Rh-negative blood type is given Rh-positive blood the body develps.. | antibodies against the Rh antigen (anit-Rh antibodies) |
After a person with type Rh-negative has developed anti-Rh antibodies, as a result of being given Rh-positive blood, what can happen if they encounter the Rh antigen again? | The persons anti-Rh antibodies will attack the Rh antigen being given causing agglutination |
An Rh-negative mother, during her first pregnany with an Rh-positive fetus, will have a _________ pregnancy. | normal |
During a 1st pregnancy, an Rh-negative persons body will develop anti-Rh antibodies (during delivery) if the fetus has what Rh factor? | Rh positive |
A mother who is Rh-negative and on her subsequent pregnancy should recieve what type of injection | RhoGAM |
If an Rh-negative mother does not recieve the RhoGAM injection, and this is not her first pregnancy what can happen? | Mothers anti-Rh antibodies could attack the fetal RBC's causing agglutination and hemolysis. |
Immune globulin is also refered to as.. | RhoGAM |
Prevents the formation of anti-Rh antibodies by the mother, thus preventing an attack on the fetus's RBC's | RhoGAM |
What are the factors of A- blood | A |
What are the factors of A+ blood | A and Rh |
What are the factors of B- | B |
What are the factors of B+ | B and Rh |
What are the factors of AB- | A and B |
What are the factors of AB+ | A, B, and Rh |
What are the factors of O- | There are no factors |
What are the factors of O+ | Rh |
Can a person who is A+ give blood to a person who is AB+ | yes |
Can a person who is A- give blood to a person who is A+ | yes |
Can a person who is B- take blood from a person who is AB- | yes |
Can a person who is AB- take blood from a person who is A- | yes |
Can a person who is O+ take blood from a person who is A+ | no |
Can a person who is A- give to a person who is AB+ | yes |
Can a person who is AB- give blood to a person who is O- | no |
Can a person who is AB+ give blood to a person who is AB- | no |
What percentage of your blood is plasma? | 55% |
What is the key protein in plasma? | Albumin |
Helps equalize fluid volume in blood | Albumin |
The 3 formed elements in blood | Erthrocytes, Leukocytes, Platelets |
Clots blood | platelets |
What are Leukocytes and what do they do? | white blood cells and fight infection |
What are Erthrocytes and what do they do? | red blood cells and carry oxygen |
What is Hematocrit? | percentage of RBC in a sample |
Viscosity | determined by the combination of plasma and blood cells. It refers to how thick or sticky a fluid is' in this case the fthickness or stickiness of blood |
The main component of plasma is | water |
WBC and platelets form a narrow buff colored band just beneath the plasma called | buffy coat |
Plasma without the clotting proteins is called | serum |
What is the heaviest formed element | Red Blood Cells |
Formation of blood cells is called | Hemopoiesis |
Red Bone Marrow produces all types of blood cells, where is red bone marrow found? | found in long bones, flat irregular bones such as the sternum, cranial bones, vertebrae, and pelvis |
Lymphatic tissues produce | lymphocytes (wbc) |
Where are lymphocytes produced? | lymphatic tissue, thymus gland, and the spleen |
RBC's cannot reproduce because they do not contain | nucleolus or DNA |
All blood cells can trace their beginnings to a specific type of bone marrow cell called a? | stem cell |
The body has two types of hemopoietic tissue | red bone marrow and lymphatic tissue |
They deliver oxygen and remove carbon dioxide | RBC |
Blood contains more RBC than any other formed element. True / False | TRUE |
A normal rbc is shaped like a with a sunken center TRUE/FALSE | True |
RBC are flexible and rubber band like TRUE/FALSE | True |
When damaged RBC's are removed from circulation the oxygen level | falls |
Declining levels of oxygen makes the kidneys respond by secreting a hormone called ? | Erthropoietin (EPO) |
EPO stimulates the red bone marrow to do what? | creating new erythrocytes or RBC's |
When the number of RBC's increase, oxygen levels will | rise |
When less EPO is produced the production of what declines? | RBC's |
How many days does it take for a RBC to mature? | 1 to 2 days |
What is an immature form of a erythrocyte called when it is release into circulation? | reticulocyte |
3 classes of blood vessels: ___, ___ and ___ | arteries, capillaries, veins |
___ carry blood away from the heart and become progressively smaller as they branch and finally result in ___. | Arteries, capillaries |
___ return blood to the heart and become progressively ___ as they merge and are closer towards it. | Veins, larger |
How many pathways do end arteries convey? | one |
Functional end arteries’ anastomosis is so tiny that they can be considered ___ ___. | end arteries |
___ vessels supply the same body region and lie next to each other. | companion |
Both artery and vein walls have 3 layers called ___. | tunics |
The right AV valve is also called the | tricuspid |
The left AV valve is called the | mitral |
The atrioventricular valves flow between the | atria and the ventricles |
The semilunar valves regulate flow between the | ventricles and the great artery |
The tricuspid valve prevents back flow from | the right ventricle to the right atrium |
The mitral valve prevents back flow from the | left ventricle to the left atrium |
The two semilunar valves are | pulmonary and aortic valves |
The pulmonary valve prevents backflow from the | pulmonary artery to the right ventricle |
The aortic valve prevents backflow from the the | aorta to the left ventricle |
The semi-rigid, fibrous, connective tissue is called the | skeleton of the heart |
The skeleton of the heart encircles each valve, it also keeps the vales from | stretching |
The 4 heart sounds | aortic area, pulmonary area, tricuspid area, mitral area |
Aortic area heart sound is located | second intercostal space, right sternal border |
Pulmonary area heart sound is located | second intercostal space, left sternal border |
Tricuspid area heart sound is located | fourth or fifth intercostal space, left sternal border |
Mitral area heart sound is located | fifth intercostal space, left midclavicular line |
The innermost layer of arteries and veins is called | tunica intima |
The middle layer of the arteries and veins is called the | tunica media |
The outer layer of artereis and veins is called the | tunica externa |
The thickest layer of the vessel is called the | tunica media |
The layer of the vessel that consists of simple squamous epithelium is | tunica intima |
The layer of the vessel that is made up of fibrous connective tissue | tunica externa |
Becomes smaller as they lead away from the heart | veins |
The 3 categories of arteries | conducting arteries, distributing arteries and arterioles |
which artery is muscular | distributing |
which artery is elastic | conducting |
which artery is resistance vessels | arterioles |
Which vessel returns blood to the heart | veins |
Which vessel carry blood away from the heart | arteries |
Which vessel connects the smallest arteries to the smallest veins | capillaries |
3 categories of veins | venules, medium sized veins and large veins |
Which is the smallest of the veins | Venules |
Which veins have one way valves | Medium sized veins |
Which veins are porous | Venules |
How much blood is circulating in the body | 5 liters |
What are 3 types of granulocytes ( wbc) | Neutrophils,eosinophils,basophils |
The two Agranulocytes | Lymphocytes and monocytes |
What wbc is the first one to get to a site of a cut | Neutrophils |
Biggest WBC | Monocyte |
WBC involved in allergic reaction | Eosinophils |
Never let my engine blow | Neutrophils-60, lymphocytes-30, monocytes-8, eosinophils- 3, basophils-0-1 |
Hemostasis | Formation of a blood clot... When we get cut |
First step in hemostasis | Vascular spasm- vessel constricts |
Second step of hemostasis | Platelets rush to area and are caught by the rough area |
Third step in hemostasis | Formation of platelet plug |
Last step in hemostasis | Tissue repair |
Thrombus | Stationary blood clot |
Mobile blood clot | Embolus |
Initiated by areas outside the blood | Extrinsic pathways |
Initiated by factors within the blood itself | Intrinsic pathways |
Naturally occurring factors that discourage clotting of blood | Smooth endothelium, blood flow, anticoagulants |
Process of moms immune system attacking her fetus | Eyrthroblastosis fetalis |
What do you need to give albumin | Signed consent |
What blood product can be gravity fed | Albumin |
Are you as the LPN allowed to hang the second bottle of albumin | Yes |
55 percent of blood is what | Plasma |
45 percent of blood is | Formed elements |
What is the clear extracellular matrix of blood | Plasma |
Insoluble protein fibers of blood clot | Fibrin |
Any of blood ejected from heart in one pump | Stroke volume |
Percent of blood that leaves the ventricle | Ejection fraction- 60-80 should leave |
Proprioceptors are found in | Muscles and joints |
Baroreceptors help do what | Regulate BP |
Chemoreceptors help maintain | Blood PH |
What three factors affect SV | Preload ...contractility and afterload |
Why do veins have the ability to constrict extensively | To prevent back flow and to help regulate blood flow |
What are the capacitance vessels | Veins |
What kind of arteries can handle high amounts of pressure | Conducting arteries |
What kind of arteries go to specific organs or sites | Distributing arteries |
What arteries connect to the capillaries and are also called resistance vessels | Arterioles |
What veins collect blood from capillaries | Venules |
What kind of veins are the radial and ulnar veins... With thicker elastic walls | Medium sized |
What kind of vein has a thick tunica externa | Large veins |
Examples of large veins | Vena cava, pulmonary, and internal jugular |
A weak spot in a vessel that bulges | Annurism |
Exchange vessels | Cappillaries |
Also called a microcirculation | Capillary beds |
How do capillaries usually make the exchange | Diffusion |
What is used to decrease edema | Albumin |
What is the path of pulmonary circulation | Unoxygenated blood leaves the right ventricle via the pulmonary arteries... Goes to lungs... Comes back with oxygen and nutrients via the pulmonary veins into the left atrium |
Are lungs nourished by pulmonary circulation | No.. They are nourished by systemic circulation |
All systemic arteries arise from | The Aorta |
Largest artery | Aorta |
Do we palpate radial and pedal pulses bilaterally at the same time | Yes |
What are we looking for with head injury | ICP... Inter cranial pressure |
Collection of vessels at the base of the skull | Circle of Willis |
Where do you find hepatic portals | Liver and kidneys |
What is the purpose of hepatic portals | Prevent heart infections |
Three factors that affect BP | Cardiac output, resistance, and blood volume |
Amount of friction depends upon | Blood viscosity and vessel diameter |
Vasoconstriction | Increases pressure and decreased flow |
Vasodilation | Decreases pressure and increases flow |
Blood velocity is fastest in | The Aorta |
Blood velosity is slowest in | Capillaries |
The two ways veins fight gravity... The two key mechanisms | Skeletal muscle pump and respiratory pump |