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Rheumatology – Aweso

Random rheum questions

QuestionAnswer
apple green birefringent with congo red amyloid deposition
what is the predictor for CVS disease in RA? homocysteine levels
Treatment for CPPD NSAIDs and intra-articular joint injections
PPX for CPPD standing NSAIDs
Leading cause of CPPD in US (1st and 2nd) hemachromatosis and hyperPTH
If you have CPPD, what should you screen patients for? (4) 1/ hemachromatosis, 2/ hyper PTH, 3/ hypothyroid, 4/ gout
hip and shoulder girdle stiffness and pain PMR
Fever of unknown origin and fatigue in someone >50yo - what to do? need to r/o giant cell arteritis, temporal biopsy; need to image the great vessels with CT chest / MRA chest to diagnose if temporal biopsy negative
how to diagnose polyarteritis nodosa Kidney and mesenteric angiography
hypertension, abdominal pain, kidney dysfunction, or mononeuritis multiplex polyarteritis nodosa
Morning stiffness lasting more than 1 hour and a synovial fluid leukocyte count greater than 5000/µL (5.0 × 109/L) are associated with inflammatory arthritis - RA
aching in the shoulders, neck, and hip girdle region; fatigue; and malaise that develop over weeks to months PMR
flowing osteophytes along the anterolateral aspect of at least four contiguous vertebral bodies. - He has neck and low back pain and limited mobility throughout the spine. This patient is male, obese, and has diabetes mellitus diffuse idiopathic skeletal hyperostosis (DISH)
calcification of the enthesis regions (where the tendons or ligaments insert into bone) and the spinal ligaments diffuse idiopathic skeletal hyperostosis (DISH)
vertical bridging syndesmophytes ankylosing spondylitis
sacroilitis + in ankylosing spondylitis, NOT in DISH
ankylosing spondylitis associated with what findings uveitis, aortitis, sacroilitis, syphilis
criteria for diagnosing antiphospholipid syndrome venous or arterial thromboembolism or pregnancy morbidity (>=3 1st trim miscarriages or 1 fetal death) and + labs (dilute Russell viper venom time, anticardiolipin antibody assay, β2 glycoprotein I antibody assay) on at least 2 occasions 12 weeks apart.
How to treat Kawasaki disease intravenous immune globulin and salicylates --> steroids if refractory (Kawasaki presents in kids and immunosuppressed
recurrent 12- to 72-hour episodes of fever with serositis (most commonly abdominal or pleural), synovitis (most often monoarticular and affecting the lower extremities), and erysipeloid rash, neutrophilic leukocytosis - how to treat? familial mediterranean fever, tx with colchicine
high ferritin, fever (less than 4h, peaks in early evening), rash (evanescent, salmon-colored, not painful, and appears on the trunk and proximal extremities), joint pain, and serositis (usually pleuritis or pericarditis) - what dx? Adult-onset Stills
acute digital ischemia in the setting of limited cutaneous systemic sclerosis - how to tx warm ambient environment, prompt attention to pain control to decrease sympathetic vasoconstriction, and institution of vasodilating therapy, preferably with a prostacyclin analogue such as epoprostenol
preventing recurrences of digital ulcers in patients with severe Raynaud phenomenon - what drug bosentan
scleroderma renal crisis - how to tx enalapril
positive lupus anticoagulant, moderate- to high-titer anticardiolipin antibodies ALP Syndrome
thrombocytopenia; hx recurrent pregnancy loss; livedo reticularis; a murmur consistent with mitral regurgitation; and elevated serum creatinine level, proteinuria, and noninflammatory urine sediment suggestive of microangiopathic kidney insufficiency ALP Syndrome
how to treat alveolitis in diffuse cutaneous systemic sclerosis Cyclophosphamide
how to treat symmetric synovitis involving the peripheral joints, tendon sheath inflammation, or (less commonly) a mild inflammatory myopathy in diffuse cutaneous systemic sclerosis with sx's of RA methotrexate
Anti–Jo-1 antibodies highly specific for the inflammatory myopathies and are associated with an increased risk for interstitial lung disease.
typical osteoarthritis features, along with chondrocalcinosis, in locations atypical for osteoarthritis such as the metacarpophalangeal joints calcium pyrophosphate (CPP) arthropathy
How do you treat ankylosing spondylitis that has not responded to NSAIDs Eternacept, TNF alpha Ab
How to treat ankylosing spondylitis with recurrent iritis or inflammatory bowel disease either infliximab or adalimumab, preferably over etanercept
How long do you treat a patient with ankylosing spondylosis with NSAIDs before you consider calling it a treatment failure? If the patient does not adequately respond to a minimum of two different trials of NSAIDs used at least 4 weeks total, Then eternacept if no axial dz or iritis. If axial or iritis, then adalimumab.
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Created by: christinapham