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Leukemia & Lymphoma

Hodgkin’s Lymphoma Localized lymph involvement & mediastinal lymphadenopathy; EBV; bimodal; M>W; fever, night sweats, wt loss; Reed Sternberg Cells (CD 15, 30, B cells)
NHL Diffuse lymph involvement; HIV/ Immunodeficiency; 20-40yo; fairly asx; B>T Cell, w no elevated AB production
Hodgkin’s Lymphoma Sub-types Nodular Sclerosing > Mixed Cellularity > Lymphocyte Predominant > Lymphocyte Depleted
Nodular Sclerosing Hodgkin’s Lymphoma (70%) Collagen banding, lacunar cells, W>M, mediastinal + 1 other painless lymphadenopathy, sweet prognosis.
Mixed Cellularity Hodgkin’s Lymphoma (25%) Shit-ton of Reed Sternbergs. OK prognosis.
Lymphocyte Predominant Hodgkin’s Lymphoma (5%) Young(ish) men. Sweet prognosis.
Lymphocyte Depleted Hodgkin’s Lymphoma (1%) Reed Sternberg > Lymphcytes. Old men. Poor prognosis.
NHL Subtypes (6) Small Lymphocytic, Follicular, Diffuse Large Cell, Mantle Cell, Lymphoblastic, Burkitt’s
Small Lymphocytic Lymphoma Adults. B Cells. Like CLL
Follicular Lymphoma t(14;18), bcl-2-> inhibits apoptosis -> hard to cure. Adults. B Cells.
Diffuse Large Cell Lymphoma Adults >> Kids. B >> T cells. ½ are curable. Most common adult NHL.
Mantle Cell Lymphoma t(11;14), Adults, B Cells.
Lymphoblastic Lymphoma Kids. Immature T’s. Most common pediatric NHL. Like ALL: Mediastinal mass. Very aggressive.
Burkitt’s Lymphoma t(8;14), c-myc -> heavy chain IgG secretion. Kids. B cells. “Starry Sky” lymphocytes w/ some macs. Jaw lesion in African endemic form, Pelvic/abdominal lesion in sporadic form.
Acute Lymphocytic Leukemia <15 yo. Treatment-responsive. TdT+ (a T & B cell marker). Spread to CNS & testes.
Acute myelocytic Leukemia 5-40 yo. Auer rods (esp. Promyelocytic/M3 form). Myeloblasts. Auer rod release -> DIC. :(
Chronic Lymphocytic Leukemia 60+ yo. Warm antibody agglutination. “smudge cells.” Lymphadenopathy & hepatosplenomegaly. Indolent course.
Chronic Myeloid Leukemia Low alk phos. Myeloid stem cell proliferation. High Neutrophil & metamyelocyte ct. -> -> Blast crisis/AML.
Age 0-14 ALL
Age 15-39 AML + auer rod
Age 40-59 AML & CML
Age 60+ CLL
Created by: Kyle Tiemeier