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Pharm 8 Antihistamin

Antihistamines. Six various classes. All block binding sites of histamine to H1 receptor sites on effector tissues. Can halt progression of type 1 hypersensitivity reaction, but can't reverse effects already present H-1 Receptor Antagonists
Cross blood-brain barrier First generation
Do not cross blood-brain barrier Second generation
Most of this class of drugs end in what? "mine"
Developed to produce less sedation and act peripherally. Second generation
Cetrizine, Fexofenadine, and Loratadine are all what? Second generation
1st line drug for hypersensitivity reaction Diphenhydramine (First generation)
Prescribed for pre-op sedation and post-op nausea. Given IM Hydroxazine (First generation)
These drugs may produce _________ s/s. Anticholinergic
Can have additive effect of ___________. CNS depressants
May block or reverse effects of other meds, such as reverse vasopressor effects of __________. Epinephrine
May mask _________, associated with aminoglycosides or large doses of salycilates. Ototoxicity
Progressive failure of adrenal gland and is generally autoimmune. Results in weakness, fatigue, anorexia, N/V, abdominal pain, dizziness, ortho hypotension, and increased skin pigmentation. Addison's Disease
Occurs from excess production or exposure to glucocorticoids. May have muscle weakness, very thin skin, weight gain (moon face), depression, easily bruised. DM can result from Tx. Steroids increase glucose production. Cushing's Syndrome
Synthetic analogs of hormones which exert antiinflammatory, metabolic, and immunosuppressant effects. Enter all tissue compartments of the body, including cerebrospinal fluid. Synthetic Glucocorticoids
Influence lipid, protein, and carb metabolism. Suppress hypersenstivity and immune responses. Enhance sodium retention. Synthetic Glucocorticoids
Replacement tx for patients with adrenal cortical insufficiency, and for antiinflammatory and immunosuppressant properties. Synthetic Glucocorticoids
Many glucocorticoids end in what? "one"
Rapid withdrawal of sythetic glucocorticoids can lead to what? Adrenocorticoid insufficiency
Anorexia, lethargy, weakness, depression, hypotension, hypoglycemia are all s/s of what? Adrenocorticoid insufficiency
Available in cream, gel, lotion, and ointment. Have anti-inflammatory effects. Used to treat acute and chronic eczema, psoriasis, and contact dermatitis. Topical Glucocorticoids
Used to treat allergic rhinitis, sneezing, and congestion Intranasal glucocorticoids
Beclomethazone and Fluticasone are what? Topical Glucocorticoids
Synthetic analogues of hormones. Admin. PO, IM, or as implanted pellets. Replacement tx in Adrenocorticoid insufficiency. Mineral Corticoids
Natural prototype of class. Use is limited by high cost, limited availability, and need for parenteral admin. Aldesterone (Mineral Corticoids)
This drug impairs synthesis of DNA, resulting in inhibited production and function of immune cells. Used in tx of CA. Also used to tx arthritis and psoriasis when not responsive to other tx. Methotrexate
This drug prevents rejection after organ transplant in patients previously treated with other immunosuppressants. Cyclosporine
Should these types of drugs be taken with or without food and/or milk? Yes. Decrease GI irritation.
What type of diet should patients be on? Low sodium
What should be monitored with use of these drugs? Blood glucose levels
Created by: mreedy