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Blood O2/Hb Content 1g Hb=1.34 mL O2
Alveolar Gas Equation PAO2 = 150-PaCO2/.8
VENTILATION Obstruction & PO2 Doesn't improve w/100% O2
PERFUSION Obstruction & PO2 Does improve w/100% O2
Reid Index Gland Depth/Bronchial wall depth. >50% -> Chronic Bronchitis
COPD PFTs Low Forced Vital Capacity, Very Low FEV1 -> Reduced FEV1/FVC Ratio.
Restrictive Lung Diseases Bleomycin(Armstrong), Bisulfan, Amiodarone. Polio, MG, Scoliosis, ARDS, Neonatal RDS, Sarcoid, Pneumoconiosis. Wegner's, Goodpasture's,
Charcot-Leyden crystals Bronchial asthma sputum findings. In addition to Curschmann spirals
IFN-Gamma Produced by macrophages -> Vascular leak-> Leukocyte recruitment & Septic shock
Thromboxane A2 Powerful platelet aggregator & vasoconstrictor. Antagonized by PGI2
LTC,D & E Vaso & broncoconstrictors, increase capilary permeability. Slow reacting substanc eof anaphylaxis
R= R=8nl/pi x r^4
LTB, HETE neutrophil chemoattractant
Churg Strauss Zafirlukast-associated. Peripheral eosinophilia, pulm infiltrates, myocarditis
IL-4 & IL-13 TH2: Induce B cells to produce IgE
Transformation "competent" bacteria Pneumococcus, H Flu, N Meningitidis
Scleroderma #1) Diffuse Scleroderma-rapidly progressive. Anti-Scl-70 AB #2) CREST Syndrome-Calcinosis, Raynauds, Esophageal dysmotility, Scerodactyly, Telangiectasia. More benign. Anticentromere AB
Anti-Centromere AB CREST Syndrome
Vitamin A (Retinol) Def: Night blindness & Dry sin. Ex: Arthralgias, skin changes, sore throat, alopecia. In leafy veggies. Pyrazinamide -> A deficiency
Interstitial Pneumonia Viruses (RSV,Adeno), Chlamydia, Leigonella, mycoplasma
Bronchopneumonia S. Aureus & Pyogenes, Klebsiella, H. Flu
Created by: Kyle Tiemeier