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P-450 INHIBITORS Ketoconazole, Isoniazide, Sulfonamides, Cimetidine, Erythromycin, Grapefruit Juice
Vd =Drug Quantity / [Plasma]
CL =Elimination Rate/ [Plasma]
Loading Dose =Vd x Desired [Plasma](Cp) / Bioavailability (F)
Gq Mediated Receptors H1,a1,V1, M1,M3 (HAV 1 M&M). Phospholipase C-> IP3 & DAG ->PKC,Ca. General SM Contraction
Gs Mediated Receptors H2,V2, b1,b2,D1 (HaVe 2 BBs,Don) Adenylyl Cyclase->PKA. General Increase HR, SM relaxation
Gi Mediated Receptors M2, a2, D2 (MAD 2s) Inhibits Adenylyl cyclase. General reduce sympathetic, HR
Alpha 1 (q) Vasoconstriction
Alpha 2 (i) Reduce Sympathetic & Insulin release
Beta 1 (s) Increase CO & Renin & Lipolysis, Aqueous humor
Beta 2 (s) Vaso & Broncho Dilation, Increase CO & Lipolysis & Glucagon
M1 (q) Central & Enteric NS
M2 (i) Reduces CO
M3 (q)Increase Exocrine, Peristalsis, Bladder Contraction
D1 (s) Renal SM Relaxation
D2 (i) Modulates CNS transmission
H1 (q) Respiratory Secretion & Bronchiole constriction, Pruritus & Pain
H2 (s) Acid secretion
V1 (q) Vasoconstriction
V2 (s) Aquaporin Fusion
Acetaminophen Toxicity N-acetylcysteine
Salicylates Toxicity NaHCO3 (alkalinize urine)
Amphetamines Toxicity (basic) NH4Cl, acidifies urine
Anticholinesterase & Organophosphate Toxicity Atropine, pralidoxime
Antimuscarinic, Anticholinergic Toxicity Physostigmine salicylate
Beta-Blocker Toxicity Glucagon
Digitalis Toxicity Stop dig, normalize K, Anti-Dig AB, Mg
Iron Toxicity Deferoxamine
Lead Toxicity CaEDTA, Dimercaprol, Succimer, Penicillamine
Arsenic, Mercury, Gold Toxicity Dimercaprol, Succimer
Copper, Arsenic, Gold Toxicity Penicillamine
Cyanide Toxicity Nitrite, Hydroxycobalamin, Thiosulfate
Methmoglobin Toxicity Methylene Blue
Carbon Monixide Toxicity 100%/Hyperbaric O2
Methanol, Ethylene Glycol Toxicity Ethanol, Dialysis, Fomepizole
Opioids Toxicity Naloxone, Naltrexone
Benzodiazepines Toxicity Flumazenil
TCA’s Toxicity NaHCO3 (Alkalinize serum)
Heparin Toxicity Protamine
Warfarin Toxicity Vitamin K, fresh frozen plasma
tPA, Streptokinase Toxicity Aminocaproic Acid
Atropine-Like Effects Tricyclics
Coronary Vasospasm Cocaine, Sumatriptan
Cutaneous Flushing Niacin, CCBs, Adenosine, Vancomycin
Dilated Cardiomyopathy Doxorubicin, Daunorubicin
Torsades des Pointes Soltalol (Class III), Quinidine (Class 1A), Cisapride
Agranulocytosis Clozapine, Carbamazepine, Colchicine, Propylthiouracil, Methimzaole
Aplastic Anemia Chloramphenicol, Benzene, NSAIDs, Propylthiouracil, Methimazole
Direct Coombs + Hemolytic Anemia Methyldopa
Gray Baby Syndrome Chloramphenicol
Hemolysis in G6PD Deficient Patients IS PAIN: Isoniazid/INH, Sulfonamides, Primaquine, Aspirin, Ibuprofen, Nitrofurantoin
Pulomonary Fibrosis Bleomycin, Busulfan, Amiodarone
Acute Cholestatic Hepatitis Macrolides
Focal-Massive Hepatic necrosis Halothane, Valproic acid, Acetaminophen
Hepatitis Isoniazid/INH
Pseudomembranous Colitis Clindamycin, Ampicillin
Adrenocortical insufficiency Glucocorticoid Withdrawal (HPA suppression)
Gynecomastia Sprionolactone, Digitalis, Cimetidine, Alcohol, Estrogens, Ketoconazole
Hot Flashes Tamoxifen, Clomiphene
Gingival Hyperplasia Phenytoin
Gout Furosemide, Thiazides
Osteoporosis Corticosteroids, Heparin
Photosensitivity Sulfonamides, Amiodarone, Tetracycline
Drug-Induced Lupus Hydralazine, INH, Procainamide, Phenytoin
Interstitial Nephritis Methicillin, NSAIDs
Hemorrhagic Renal Cystitis Cyclophosphamide, Isofosfamide
Cinchonism Quinidine, Quinine
Diabetes Insipidus Lithium, Demeclocycline
Seizures Bupropion, Imipenem/Cilastin
Disulfram-like Rx Metronidazole, Cephalosporins, Procarbazine, First-Gen Sulfonylureas
Neprhotoxic/Neurotoxic Polymyxins
Nephrotoxic/Ototoxic Aminoglycosides, Loop Diuretics, Cisplatin
P-450 Inducers Quinidine, Barbituates, Phenytoin, Rifampin, Griseofulvin, Carbamazepine, St. John’s wort
P-450 Inhibitors Isoniazid, Sulfonylureas, Cimetidine, Ketoconazole, Erythromycin, Grapefruit Juice.
Sulfa Drugs Celecoxib, Furosemide, Thiazides, TMP-SMX, Sulfonylureas, Sulfasalazine
Created by: Kyle Tiemeier