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Agonist/Antagonists

Pharm (Test 2)

QuestionAnswer
Describe the receptor affinity of Pentazocine (Talwin). weak mu antagonist, partial kappa agonist
What are the indications for Pentazocine (Talwin)? moderate pain, chronic pain, inc. risk of physical dependence
What are the effects of Pentazocine (Talwin)? analgesia, sedation, mild resp. depression
Describe the CV effects of Pentazocine (Talwin). inc. HR, cardiac workload, SBP, PA pressure, and myocardial O2 consumption
What patients have special considerations for the use of Pentazocine (Talwin)? IHD, CHF, MI, pregnant mothers
Does narcan antagonize Pentazocine (Talwin)? yes
Does Pentazocine (Talwin) antagonize resp. depression? no
Describe the receptor affinity of Butorphanol (Stadol). more kappa than mu or sigma
Compare potency between Talwin and Stadol. Stadol is 20X more agonist potent and 10-30X more antagonist potent than Talwin
Compare analgesic potency between Butrophanol (Stadol) and morphine. stadol has more analgesic potency than morphine
What are the indications of Butrophanol (Stadol)? post-op pain, migraine headaches, post-op shivering
What are the effects of Butrophanol (Stadol)? analgesia, resp. depression
What are some side effects of Pentazocine (Talwin)? (DD) sedation, dysphoria, diaphoresis, dizziness, dissociation, "weird" feelings, hallucinations, NO mood elevation
What are some side effects of Butorphanol (Stadol)? withdrawal after d/c, sedation, nausea, diaphoresis, resp. depression, dissociation, dysphoria is RARE
Describe the CV concerns with Butrophanol (Stadol). inc. CO, cardiac workload, SBP and PA pressure
What patients have special considerations for the use of Butrophanol (Stadol)? CHF and MI pts
Which agonist/antagonist has a nasal spray? Stadol
Describe the receptor affinity of Nalbuphine (Nubain). mu antagonist, kappa agonist
Compare the potency of Nalbuphine (Nubain) to morphine. very comparable
What are the indications for use of Nalbuphine (Nubain)? reversing fent-induced resp. dep; antagonizes pruritis induced by epidural morphine
What are the effects of Nalbuphine (Nubain)? kappa provide adequate pain relief w/ less resp. depression, analgesia, sedation
What are the side effects of Nalbuphine (Nubain)? withdrawal after d/c, diaphoresis, headache, dissociation
Describe the CV concerns for Nalbuphine (Nubain). none
Does narcan antagonize stadol? no
Does narcan antagonize Nubain? yes
True or False: Nalbuphine (Nubain) has a ceiling for respiratory depression. True
Describe the receptor affinity of Buprenorphine (Buprenex). partial mu agonist, mu antagonist
Describe the receptor affinity of Buprenorphine (Buprenex) to that of morphine. Buprenex's affinity for mu receptor is 50X greater than morphine
What are the indications for use of Buprenorphine (Buprenex)? reversing fent-induced resp. dep; effective on moderate to severe cancer pain; opioid dependence
What are some side effects of Buprenorphine (Buprenex)? withdrawal after d/c, sedation, n/v, diaphoresis, headache, dizziness
Does narcan antagonist Buprenorphine (Buprenex)? no
Which a/a can treat migraine headaches? stadol
Which a/a(s) can be used to treat fent-induced resp. dep? nubain, buprenex
Which a/a(s) can cause withdrawal after d/c? stadol, nubain, buprenex
Which a/a(s) cause inc. HR, SBP, cardiac workload, etc? talwin, stadol
Which a/a(s) can be antagonized by narcan? talwin, nubain
Which a/a is available in a nasal spray? stadol
Which a/a has a potency comparable to morphine? nubain
Which a/a has a ceiling resp. depressant effect? nubain
Which a/a can cross the placental barrier and cause fetal depression? talwin
Which a/a(s) are kappa agonists? talwin, stadol, nubain
Which a/a can cause "weird" feelings and hallucinations? talwin
Which a/a is effective for cancer pain? buprenex
Which a/a has a mu receptor affinity 50X greater than morphine? buprenex
Which a/a has analgesic potency greater than morphine? stadol
Which a/a can be used to treat post-op shivering? stadol
Which a/a antagonizes the pruritis induced by epidural morphine? nubain