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Lipid Lowering Drugs

statins (e.g. lovastatin, pravastatin, simvastatin) inhibit HMG-CoA reductase in liver; adverse effects: MYOSITIS, increased LFTs
Ezetimibe inhibits cholesterol absorption in intestines to significantly decrease LDL (no effect on HDL or triglycerides); adverse effects: myalgias, possible increased LFTs
Fibric acids (e.g. gemfibrozil, fenofibrate) stimulate lipoprotein lipase in blood to decrease LDL, increase HDL, and *significantly decrease triglycerides*; adverse effects: MYOSITIS, increased LFTs
Bile acid sequestrants (e.g. cholestyramine, colestipol, colesevelam) bind to bile acids in the intestine and prevent them from being reabsorbed into the blood to decrease LDL; adverse effects: bad taste, GI upset
Niacin MOA unknown, but acts in liver to decrease LDL, decrease triglycerides, and *significantly increase HDL*; adverse effects: facial flushing, nausea, paresthesias, pruritus, increased LFTs, insulin resistance, exacerbates gout
Created by: hewit051



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