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HIGH ALERT
use with caution
| DRUG | DESCRIPTION | BRAND NAME |
|---|---|---|
| Amikacin Peak 25-30; trough <10 mcg/mL | Amikacin For short-term treatment of serious infections like E.Coli, Gram (-) Bacteria, Neonatal Sepsis,respiratory tract, bones & joints, meningitis, skin & soft tissue, peritonitis, & in burns and post-OP vascular surgery | Amikacin Peak 25-30; trough <10 mcg/mL AMIKACIN SULFATE |
| Amiodarone 1.0-3.0 mcg/mL | Amiodarone For ventricular arrhythmias | Amiodarone 1.0-3.0 mcg/mL CORDARONE, CORDARONE IV, AMIODARONE HCL injection |
| Amitriptyline 100-250 ng/mL | Amitriptyline For the relief of symptoms of depression. Endogenous depression is more likely to be alleviated than are other depressive states. | Amitriptyline 100-250 ng/mL ELAVIL, ETRAFON |
| Carbamazepine 4-10 mcg/mL | Carbamazepine For epilepsy as an anti-convulsant & true trigeminal neuralgia | Carbamazepine 4-10 mcg/mL TEGRETOL, CARBATROL, EQUETRO |
| Chloramphenicol Peak 10-15; trough <5 mcg/mL | Chloramphenicol For surface ocular infections involving the conjunctiva and/or cornea caused by chloramphenicol-susceptible organisms. Strep. pneumoniae, E. coli, H. influenzea, Klebsiella/Enterobacter species; Moraxella lacunata & Neisseria species. | Chloramphenicol Peak 10-15; trough <5 mcg/mL CHLOROPTIC |
| Desipramine 150-300 ng/mL | Desipramine For the treatment of depression. | Desipramine 150-300 ng/mL NORPRAMIN |
| Digoxin 0.8-2.0 ng/mL | Digoxin For the treatment of mild to moderate heart failure. Should be used with a diuretic and an angiotensin-converting enzyme inhibitor | Digoxin 0.8-2.0 ng/mL LANOXIN INJ., DIGITEK, DIGIBIND |
| Disopyramide 2-5 mcg/mL | Disopyramide For the treatment of documented ventricular arrhythmias, (ventricular tachycardia) that are life-threatening. Treatment of patients with asymptomatic ventricular premature contractions should be avoided. | Disopyramide 2-5 mcg/mL NORPACE |
| Doxepin 75-200 ng/mL | Doxepin For depression &/or anxiety associated with alcoholism, tension, somatic symptoms and concerns, sleep disturbances, guilt, lack of energy, fear, apprehension and worry (not to be taken with alcohol). | Doxepin 75-200 ng/mL SINEQUAN, PRUDOXIN, ZONALON |
| Flecainide 0.2-1.0 mcg/mL | Flecainide For the prevention of paroxysmal supraventricular tachycardias (PSVT),paroxysmal atrial fibrillation/flutter (PAF), atrioventricular nodal reentrant tachycardia & documented ventricular arrhythmias. | Flecainide 0.2-1.0 mcg/mL TAMBOCOR |
| Gentamicin Peak 6.0-8.0; trough <2.0 mcg/mL | Gentamicin For topical treatment of ocular bacterial infections like conjunctivitis, keratitis, keratoconjunctivitis, corneal ulcers, blepharitis, blepharoconjunctivitis, acute meibomianitis, and dacryocystitis. | Gentamicin Peak 6.0-8.0; trough <2.0 mcg/mL GENOPTIC, GENTAMICIN PEDIATRIC, PRED-G |
| Imipramine 150-300 ng/mL | Imipramine For the relief of symptoms of depression. Endogenous depression is more likely to be alleviated than other depressive states. 1-3 wks of tx may be needed before optimal therapeutic effects are evident & also for Childhood Enuresis. | Imipramine 150-300 ng/mL TOFRANIL, TOFRANIL-PM |
| Lidocaine 2-5 mcg/mL | Lidocaine For production of local or regional anesthesia | Lidocaine 2-5 mcg/mL XYLOCAINE, AKTEN, EMLA, LIDODERM, XYLOCAINE VISCOUS |
| Lithium 0.5-1.4 mEq/L | Lithium For treatment of manic-depressive illness. Maintenance therapy prevents or diminishes the intensity of subsequent episodes to patients with a history of mania. | Lithium 0.5-1.4 mEq/L ESKALITH |
| Nortriptyline 50-150 ng/mL | Nortriptyline For the relief of symptoms of depression. Endogenous depressions are more likely to be alleviated than are other depressive states. | Nortriptyline 50-150 ng/mL NORTRIPTYLINE HCL (CAPS, ORAL) PAMELOR |
| Phenobarbital 10-30 mEq/mL | Phenobarbital For the short-term treatment of insomnia. Long term, generalized tonic-clonic and cortical local seizures associated with status epilepticus, cholera, eclampsia, meningitis, tetanus,(hypnotic, sedative, preanesthetic) | Phenobarbital 10-30 mEq/mL PHENOBARBITAL |
| Phenytoin 8-20 mcg/mL (4-10 mcg/mL) in presence of significant azotemia and/or hypoalbuminemia | Phenytoin For the control of generalized tonic-clonic (grand mal) and complex partial (psychomotor, temporal lobe) seizures and prevention and treatment of seizures occurring during or following neurosurgery. | Phenytoin 8-20 mcg/mL (4-10 mcg/mL) in presence of significant azotemia and/or hypoalbuminemia DILANTIN |
| Procainamide 4.0-8.0 mcg/mL | Procainamide For the treatment of documented ventricular arrhythmias | Procainamide 4.0-8.0 mcg/mL PRONESTYL, PROCAN SR |
| Quinidine 2.5-5.0 mcg/mL | Quinidine For the suppression of recurrent documented ventricular arrhythmias. Indicated as a means of restoring normal sinus rhythm, discontinue if this not achieved. | Quinidine 2.5-5.0 mcg/mL QUINIDEX, QUINIDINE GLUCONATE, QUINIDINE INJECTION |
| Theophylline 8-20 mcg/mL | Theophylline For the treatment of the symptoms and reversible airflow obstruction associated with chronic asthma and other chronic lung diseases, e.g., emphysema and chronic bronchitis. | Theophylline 8-20 mcg/mL THEO-DUR, SLO-PHYLLIN, THEOPHYLLINE IN 5% DEXTROSE INJ. , LUFYLLIN |
| Valproic acid 50-100 mcg/mL | Valproic acid For monotherapy and adjunctive therapy in the treatment of patients with complex partial seizures that occur either in isolation or in association with other types of seizures | Valproic acid 50-100 mcg/mL DEPAKENE, STAVZOR |
| Vancomycin Peak 30-40; trough <10 mcg/mL | Vancomycin For the tX of serious or severe infections caused by susceptible strains of methicillin-resistant (beta-lactam-resistant) staphylococci. It is indicated for penicillin-allergic patients | Vancomycin Peak 30-40; trough <10 mcg/mL VANCOMYCIN INJECTION |