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Anectine
Neuromuscular Blocking Agents
Question | Answer |
---|---|
What is the prototype drug for neuromuscular blocking agents? | succinylcholine (Anectine) |
What is their purpose? What does this cause (2)? | To block acetylcholine (ACh) at the neuromuscular junction, causing muscle relaxation & hypotension |
Benefit of neuromuscular blocking agents? | Do NOT cross the blood-brain barrier, allowing PARALYSIS withOUT loss of consciousness |
Therapeutic Uses (4) | 1.) Used as adjunct to general anesthesia to promote muscle relaxation 2.) mechanical ventilation 3.) seizure control 4.) during intubation & endoscopies |
Major adverse effect? | Malignant hyperthermia |
If signs of malignant hyperthermia present...(4) | 1.) STOP medication 2.) administer 100% oxygen 3.) Initiate cooling measures 4.) Administer DANTROLENE |
What lab value needs to be monitored? | Potassium...this medication can cause hyperkalemia |
What are the TWO main organs we are concerned with while taking this medication? | HEART & LUNGS! This medication can cause HTN/bradycardia & respiratory arrest |
A patient taking this medication should ALWAYS be on... | A HEART monitor! |
How often do we assess vitals while this patient is taking this medication? | Every FIVE minutes |
What pregnancy category is this medication? | C |
After surgery, it is important to monitor the patient for... | Return of respiratory function & movement. This medication can cause respiratory arrest! |