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Pharmaceutics 18-20

Dispersion types (Liquid) In solid: cheese Solid Emulsion In liquid: Milk Emulsion In: gas: Fog, cloud Liquid aerosol
Dispersion types (Gas) In solid: Marshmallow Solid foam In liquid:Whipped Cream Foam N/A
Colloidal dispersions Micelles, Liposome, microemulsion, nano/microparticle, nano crystal, biopharmaceuticals
Coarse dispersions Suspensions,emulsions, foam, some aerosol
Suspension insoluble particles dispersed in liquid medium Antibiotics, Antacids, radiopague, topical
Advantages of suspensions better chemical stability than solution, increased delivery rate than solid, allows liquid dosing of unpalitability
Disadvantages of suspensions don't really uniformly disperse, agglomerate(aggregate to cluster), particles settle, cake up Dosage accuracy problems, homogeneity problems, stability problems, compliance problems
Increased surface area Increased interfacial energy, not thermo stable
Homogeneity dose consistency and evenness
Viscosity pour readily, spread easily on skin or easily go through a syringe
Settlement Should settle slowly and easily reversable
Particle size Should remain constant
Electric Properties of Interfaces Particles dispersed in liquids may become charged
Electric Double Layers 1st: tightly bound layer 2nd: Diffuse
Tightly bound layer dense layer of counter ions strongly attached to the surface (rigid layer)
Diffuse layer A diffuse layer of counter ions trying to approach the particle (shear plane)
Nernst potential Electric potential at a solid's surface Drops rapidly across tightly bound layer More gradually across the diffuse layer
Electro-kinetic(zeta) potential Potential located at the shear plane can be +, 0, or - Magnitude of zeta potential has implication for the stability of dispersed system related to ionic environment of the liquid phase
Dispersed System(dispersion) Continuous media:external phase, vehicle, media Dispersed phase: internal phase, matter dispersed
Dispersion types(Solid) In solid: pearls solid solution In liquid: Jelly gel In gas: Smoke Solid aerosol
Created by: samselsw