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Brain&Behavior Ch8.1
Neuroendocrinology
| Term | Definition |
|---|---|
| What are the four types of chemical communication? | endocrine, synaptic, pheromone, and allomone |
| endocrine communication | in endocrine communication a hormone is released into the bloodstream to selectively act on target tissues |
| synaptic communication | chemical release and diffusion across a synapse |
| pheromone communcation | chemicals released outside the body to affect other individuals of the same species are pheromones |
| allomone communication | chemicals released outside the body to affect individuals of another species are allomones |
| ________ and _______ communication overlap and are continuous with one another | Neural and hormonal |
| how are hormones similar to neurotransmitters? | they act as signals to the body and act on cells with specific receptors |
| how are hormones different from neurotransmitters? | they are released into the bloodstream and have diffuse effects |
| Some endocrine glands release classic _____________ | neurotransmitters |
| Some neurons release what? | substances once thought to be exclusively peripheral hormones |
| Some of the cells of the brain act both like _______ and like _________ cells | neurons, endocrine cells |
| hormones | chemicals, secreted by one cell group, that travel through the bloodstream to act on targets through specialized receptors |
| endocrine glands do what? | release hormones WITHIN the body |
| exocrine glands do what? | use ducts to secrete fluid OUT of the body (tears and sweat) |
| anabolic steroids | Man-made substances related to male sex hormones |
| What are the different uses for anabolic steroids? | Used to treat hormonal problems in heterosexual and transgender men, delayed puberty, and muscle loss from disease. Athletes use it build muscles and improve athletic performance (illegal or unsafe) |
| the affects of anabolic steroids in men | Breast growth and shrinking of testicles |
| the affects of anabolic steroids in women | Voice deepening and growth of facial hair |
| other effects of anabolic steroids | acne, heart attack, high blood pressure, kidney damage, liver disease (cancer), and aggressive behavior |
| When we think of hormones, we think of what four things? | sex, aggression, stress, and social behavior |
| sex | -reproduction, child birth and nursing -gender preference & identity |
| aggression | violent crimes, explosive behavior |
| stress | hippocampal atrophy, neuronal death |
| social behavior | mood, altruism, pro/anti social behavior |
| effects of castration: __________ noted that roosters who are castrated when young do not develop properly in body or behavior | Aristotle |
| 1849 German physician Arnold Berthold did an experiment to show how testes affect the body. How did he do this? | He re-implanted one testis in body cavity. The roosters developed normal anatomy and behavior |
| What did Berthold conclude from his experiment? | that the effects were due to a substance |
| We would learn later that this hormone is __________ and that re-implanting only works in developing animal | testosterone |
| how can hormones be classified by? | chemical structure |
| Protein hormone, or peptide hormone | a hormone that consists of a string of amino acids |
| Amine hormones | modified version of a single amino acid, called monoamine hormones (melatonin, adrenaline) |
| Steroid hormones | derived from cholesterol and made of four rings of carbon atoms (estrogen, testosterone) |
| these three classes of hormones exert influences in _#_ different ways: | 2 |
| 1. Protein and amine hormones do what? | bind to specific receptors on the SURFACE of a cell |
| 1. the binding of protein and amine hormones to the receptors cause what? | release of a chemical signal,a second messenger, in the cell |
| these hormones are “____” acting hormones | fast (seconds – minutes) |
| 2. steroid hormones do what? | pass through the cell membrane and bind to receptors inside the cell |
| these hormones are “____” acting hormones | slow |
| The steroid-receptor complex binds to specific regions of DNA and controls what? | expression of specific genes |
| Almost all hormones act on more than one ______ organ | target organ |
| What are some effects of testosterone? (3) | • Triggers sperm generation • Facial hair, deep voice and more muscles • Triggers brain regions responsible for sexual behavior and aggression |
| A hormone may have different effects on each target, and act to c_________ different parts of the body | coordinate |
| One hormone may cause a response in more than one type of r_______ | receptor |
| One target organ may respond to several __________ | hormones – this is especially true in the brain |
| Multiple receptors are sensitive to same __________ | hormone |
| The same receptor may respond differently to same hormone when present on d_________ cells | different |
| Hormones rarely act a______ | alone |
| Many endocrine glands in the body. The _________ gland releases several hormones and regulates many endocrine glands | pituitary |
| pituitary stalk connects ________ to __________ | pituitary to hypothalamus |
| What are the two parts of the pituitary? | the anterior pituitary(front) and the posterior pituitary(rear) |
| Posterior pituitary: Neuroendocrine cells in the supraoptic and paraventricular nuclei of the h__________ produce h_________ | hypothalamus, hormones |
| Posterior pituitary: _______ _________ in hypothalamic neuroendocrine cells trigger release of hormone onto the c_________ in the posterior pituitary | Action potentials, capillaries |
| Posterior Pituitary releases 2 hormones into the bloodstream: | Oxytosin and Vasopressin |
| Neuroendocrine cells | specialized neurons that release hormones into the blood |
| Posterior Pituitary: Where do these action potentials come from? | neuroendocrine cells receive synaptic signals from other neurons and produce action potentials |
| Posterior Pituitary: These action potentials trigger the release of hormones. Thus, the ________ signal is being converted to a ________ signal | electrical, hormonal |
| Posterior Pituitary: oxytocin is involved in...(3) | reproductive and parenting behavior, uterine contractions, and milk letdown reflex |
| Posterior Pituitary: milk letdown reflex | reflexive release of milk by the mammary glands of a nursing female in response to suckling |
| milk letdown reflex: begins with sensory stimulation of receptors in the nipple that send signal to the _______ and then to the __________ | cortex, hypothalamus |
| mild letdown reflex: cells in the hypothalamus produce oxytocin and release it from the posterior pituitary. The oxytocin causes the cells of the _________ glands to contract, releasing milk | mammary |
| Posterior Pituitary: Oxytocin release increases pleasurable feelings during orgasm for men or women? | both men and women. ;) |
| Posterior Pituitary: an oxytocin–producing cell knockout mouse and makes them unable to recognize the _____ of previous female partners | smell |
| Posterior Pituitary: Infusion of oxytocin cures “social _______” | amnesia |
| Posterior Pituitary: Arginine vasopressin (AVP), or vasopressin – promotes _______ conservation and increases _______ _________ | water conservation, blood pressure |
| Posterior Pituitary: prarie voles couples form stable pair-bonds, which means what? | a durable and exclusive relationship between a male and a female |
| Posterior Pituitary: in male praire voles, it is __________ rather than _________ that facilitates the formation of a preference for female partners. | vasopressin, oxytocin |
| Posterior Pituitary: __________ Prairie Voles have dense concentrations of vasopressin receptors in the ventral pallidum (VP). Related _____________ Meadow Vole have fewer vassopressin receptors | Monogamous, non-monogamous |
| anterior pituitary contrary to posterior pituitary, contains __________ cells that synthesize and secrete different hormones | endocrine |
| the anterior pituitary hormones are called ________ hormones | tropic |
| anterior pituitary: Tropic hormones are pituitary hormones that affect _________ by other endocrine glands | secretion |
| anterior pituitary: Tropic hormones have ______ glands with specific hormone receptors (are created in the ant. pit.) | target |
| anterior pituitary: _________ hormones are used by the h__________ to control the release of tropic hormones | Releasing, hypothalamus |
| anterior pituitary: Neuroendocrine cell axons that produce releasing hormones converge on the ________ _________ and release hormones into ___________-________ ________ | median eminence, hypothalamic-pituitary portal |
| anterior pituitary: The median eminence contains ______ ________ that form the hypothalamic-pituitary portal system | blood vessels |
| anterior pituitary: Hypothalamic neurons synthesize releasing hormones that are secreted into _____ blood vessels and travel to the anterior pituitary | local |
| anterior pituitary: The secretion rate of releasing hormones governs the rate of what into the general circulation? | tropic hormone release |
| Hormone secretion is controlled by the brain in response to ________ and _______ cues | internal and external |
| Hormone release from neuroendocrine cells is regulated by a ________ system | feedback |
| Negative feedback – output feeds back and ______ signals for further secretion | inhibits |
| Hypothalamic neurons that synthesize releasing hormones are sensitive to two influences: | Circulating messages and Synaptic input |
| Circulating messages such as other hormones contribute to _________ feedback | negative |
| Synaptic input from other brain regions can be _________ or ___________ | inhibitory or excitatory |
| Circulating stress hormones can halt the production of G_____ ________ | Growth hormone |
| Growth hormone (GH): what kind of hormone is it and what is it secretes by? | a tropic hormone secreted by the anterior pituitary |
| In psychosocial dwarfism the brain does not produce the releasing hormones that stimulate GH secretion, and growth is ______ | stunted |
| Growth rates of abused children before and after the removal of abusive situation shows an immediate _______ in height | spike |
| Two anterior pituitary tropic hormones act on the gonads (ovaries and testes): what these collectively known as? | the gonadotropins |
| Two anterior pituitary tropic hormones act on the gonads: The ___________ controls gonadal hormone production by releasing __________ _________-_________ into the median eminence | hypothalamus, gonadotropin releasing-hormone (GnRH) |
| Two anterior pituitary tropic hormones act on the gonads: GnRH stimulates the anterior pituitary to release one or both gonadotropins. What are these gonadotropins? | Follicle-stimulating hormone (FSH) and luteinizing hormone (LH) |
| Two anterior pituitary tropic hormones act on the gonads: Follicle-stimulating hormone (FSH) stimulates what? | egg-containing follicles or sperm production |
| Two anterior pituitary tropic hormones act on the gonads: Luteinizing hormone (LH) stimulates follicles to form the _________ _______ in women, or ___________ production in males | corpora lutea, testosterone |
| Then the gonads produce steroid hormones and regulate ___________ | reproduction |
| Each testis or ovary has two compartments: one to produce ________ and one to produce _________ | hormones, gametes (eggs or sperm) |
| Testes produce and secrete testosterone, one of the male hormones called ________ | androgens |
| Ovaries produce two main classes of hormones: | Progestins (such as progesterone) and Estrogens (such as estradiol) |
| how does the ovulatory cycle begin? | when FSH stimulates ovarian follicles to grow and secrete estrogens |
| Oral contraceptives contain small amounts of synthetic hormones which exert ________ feedback on the hypothalamus, ________ GnRH | negative, inhibiting |
| Without ______, no FSH or LH is released and the ovary does not release an egg for fertilization | GnRH |
| Hormonal and neural systems work together, and communicate in four ways: | Neural-to-neural, Neural-to-endocrine, Endocrine-to-endocrine, and Endocrine-to-neural |
| the male ringdove sees an attractive female. The stimulation of his retina sets off a chain of ________-to-_________ transmission of information | neural-to-neural |
| the male's perception of an available mate activates a ________-to-__________ link as neurosecretory cells in his hypothalamus secrete GnRH into the hypothalamic-pituitary portal system | neural-to-endocrine |
| the pituitary mediates an ________-to-_________ signal, releasing LH and FSH. these hormones provide and __________-to-__________ signal, inducing eh testes to increase production and release of the hormone testosterone | endocrine-to-endocrine |
| tertosterone, in turn, uses an ___________-to-__________ link, altering the excitability of some brain neurons and thus causing the male to display courtship behavior | endocrine-to-neural |
| the female dove responds to his display, thus providing new visual stimulation to the male and further _________-to-_________ signals within his brain. Then the cycle begins again | neural-to-neural |
| The hormonal and neural systems exert reciprocal influences on each other: a cycle of change in _______ ________ to change in __________ to change in _________ back to the beginning of the cycle | hormone release, behavior, experience |