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PCol - Exam 2

cholinergic agonists (direct acting)

ACh endogenous NT (not a good drug because rapidly metabolized); clinical use = produce complete miosis in eye surgery
Methacholine muscarinic selective, slightly longer duration of action; clinical use = bronchial airway hypersensitivity testing (diagnostic tool)
Carbachol carbamic acid derivative of ACh designed for longer duration of action (resists hydrolysis once bound to AChE); used in the eye to target the desired tissue, but not nicotinic/muscarinic selective; clinical use = produce complete miosis in eye surgery
Bethanechol added methyl to carbachol makes bethanechol; long-acting (resists hydrolysis) and selective for muscarinic receptors; bladder and GI hypotonia
Pilocarpine muscarinic agonist, binds AChE but resists hydrolysis (making it longer acting); used for treatment of open-angle glaucoma; natural product; can also be used clinically for Sjorgen’s syndrome
Cevimeline synthetic pilocarpine-like molecule; approved for Sjorgen’s syndrome
Oxotremorine muscarinic selective; long acting (resists AChE hydrolysis); clinical use = experimental model of Parkinson’s disease tremor
Created by: Krafty