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USMLE

Comprehensive Pharm 10

QuestionAnswer
MOA orlistat inhibits pancreatic lipase
clinical use of orlistat obesity management
toxcicity of orlistat gi discomfort steatorrhea reduced absorption of fat soluble vitamins ha
MOA sibutramine sympathommimetic 5HT and NorE reuptake inhibitor
uses of sibutramine short term and long term obesity management
toxicity of sibutramine htn tachycardia
uses of GH GH deficiency turner's syndrome
uses of somatostatin acromegaly carcinoid gastrinoma glucagonoma
uses of octeroitide (aka somatostatin) acromegaly carcinoid gastrinoma glucagonoma
uses of adh pituitary DI
MOA propylthiouracil inhibits organification and coupling of thyroid hormone synthesis decreased peripheral conversion of T4 --> T3
Which drugs block peptidoglycan cross-linking Cephalosporin -cillins -nam/-nem
which drugs block peptidoglycan synthesis? bacitracin vancomycin cycloserine
which drugs block bacterial/fungal cell wall synth polymyxins
which drugs disrupt fungal cell membranes amphotericin b nystatin -azoles
which drugs block NT synth "Try my cell phone - I blocked the New Cleo" Sulfonamides trimethoprim
which drugs block DNA synth "TOPless DANcing Queen" (insert abba song here... :) Topoisomerase Quinolones
which drugs block mRNA synth rifampin
Which drugs block protein synth at the 50S subunit? -mycins linezolid -gramins macrolides chloramphenicol
which drugs block protein synth at the 30S subunit Aminoglycosides tetracyclines
MOA penicillin it binds to penicillin binding proteins blocks the cross-linking of peptidoglycan activates autolytic enzymes
uses for penicillin gram + cocci and rods GNR spirochetes
which penicillins are the penicillinase resistant? Nafcillin dicloxacillin methicillin
clinical uses for penicillinase resistant penicillins? S. aureus (except for MRSA)
why are penicillinase resistant penicillins resistant to penicillinase bulikier R group
how is MRSA resistant to methicillin altered penicillin binding protein target site
adverse reaction to methicillin interstitial nephritis
examples of aminopenicillins ampicillin amoxicillin
what is clavulanic acid penicillinase inhibitor
clinical uses for aminopenicillins "ampicillin/amoxicillin HELPS kill enterococci" H. influenza e. coli Listeria monocytogenes Proteus mirabilis Salmonella Enterococci
anti-pseudomonal drugs "Take Piper in the Car, Sue" ticarcillin piperacillin carbenicillin
MOA cephalosporins same as penicillins, less susceptible to penicillinases
uses for 1st generation cephalosporins PEcK Proteus E coli Klebsiella
uses for 2nd generation cephalosporins HEN PEcKS H. flu Enterobacter Neisseria Proteus E. coli Klebsiella Serratia
examples of 1st generation cephalosporins "You FAILed the FIRST PHASE" cefazolin cephalexin
examples of 2nd generation cephalosporins "Wait a SECOND! You SEE, FOX FUR is a FACt" cefoxitin cefuroxime cefaclor
3rd generation cephalosporins "If you are THIRsty, try a FOTO TAZER" Cefotaxime Ceftazidime ceftriaxone
clinical uses of aztreonam klebsiella pseudomonas serratia (GNR only, nothing against gm + or anaerobes)
who is given aztreonam penicillin allergic pts pts w renal insuff that can't tolerate aminoglycosides
what is cilastatin? inhibits renal dihydropeptidase I always administered with imipenem
clinical uses for imipenem/meropenem? gram + cocci GNR anaerobes
toxicity of imipenem, meropenem gi distress rash seizures (all occcur at high plasma levels)
MOA aminoglycosides 'cidal/static? inhibits formation of initiation complex --> misreads mRNA requires O2 for uptake, so won't work against anaerobes 'cidal
which drugs are aminoglycosides? "Mean GNATS canNOT kill anaerobes" Gentamicin Neomycin Amikacin Tobramycin Streptomycin
toxicity of aminoglycosides "Mean GNATS canNOT kill anaerobes" Nephrotoxicity (esp if used with cephalosporin) Ototoxicity (esp w/ loop diuretic) Teratogen
Uses for tetracyclines VACUUM THe BedRoom Tunight V. cholera Acne Chlamydia Ureaplasma Urealyticum Mycoplasma pneumoniae Tularemia H. Pylori Borrelia Burgodorferi Rickettsia
MOA tetracyclines 'cidal/static? binds 30S and prevents attachment of aminoacyl RNA static
foods to avoid when takin tetracyclines don't take with milk, iron, or antacids b/c it will inhibit absorption in gut
which tetracycline is fecally eliminated? doxycycline (can be used in renal failure)
toxicity of tetracyclines photosensitivity gi discomfort discoloration of teeth inhibits bone growth in kids
contraindications of tetracyclines pregnancy
what drug can act as a diuretic in SIADH demeclocycline (ADH antagonist)
Created by: Asclepius