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USMLE

Comprehensive Pharm 2

QuestionAnswer
MOA phenytoin Increases Na channel inactivation
MOA carbamazepine Increases Na channel inactivation
MOA lamotrigine blocks voltage gated Na channels
MOA gabapentin increases GABA release
MOA topiramate Blocks Na channels, increases GABA release
MOA phenobarbital increases GABA
MOA valproic acid increases GABA, blocks Na channels
MOA ethosuxamide blocks ca channels in thalamus
MOA benzos increases GABA
uses for phenytoin everything but absence seizures. status epilepticus prophylaxis
usees for lamotrigine everything but status epilepticus
uses for carbamazepine everything but absence and status
uses for gabapentin all seizures except absence and status peripheral neuropathy
uses for topirimate everything but absence and status
uses for phenobarbital everything but absence and status
uses for valproic acid everything but status
uses for ethosuxamide absence
uses for benzos in epilepsy acute status
which anti-epileptic drugs are 1st line in pregnancy and children phenobarbital
which epi drug is 1st line for trigeminal neuralgia carbamazepine
which drug is used to treat peripheral neuropathy gabapentin
which drug is used to treat myoclonic seizures valproic acid
which drug is used to treat seizures in eclampsia MgSO4 (1st line) benzos
which epileptic drug --> sedation, tolerance, and dependence? benzos
which epileptic drug --> aplastic anemia, liver toxicity, and teratogenesis? carbamazepine
which epileptic drug --> diplopia, ataxia? carbamazepine phenytoin
which epileptic drug --> GI distress, lethargy, headache? ethosuxamide
which epileptic drugs --> stevens johnson syndrome ethosuxamide lamotragine
which epileptic drug --> nystagmus, gingival hyperplasia, hirsutism? phenytoin
which epileptic drug --> SLE like sydnrome phenytoin
which epi drug --> spina bifida and other NTDs valproic acid
which epi drug --> kidney stones topiramate
which epilepsy drug --> malignant hyperthermia? phenytoin
how do you treat OD of barbiturates? symptom management
how do you treat OD of benzos? flumazenil (competitive antagonist at GABA receptor)
other than for epilepsy, what can phenytoin be used for? anti-arrhythmic
which is more dangerous in overdose: benzos or barbiturates? barbiturates (longer t1/2 and more respiratory/cv depression)
MOA l-dopa l dopa crosses bbb (dopamine doesn't) so it is converted to dopamine by dopa decarboxylase in CNS
carbidopa peripheral decarboxylase inhibitor in order to increase bioavailability in brain and decrease peripheral side effects (since the conversion to dopamine won't occur peripherally)
toxicity of l-dopa? arrhythmias from peripheral conversion of DA dyskinesia following lt admin akinesia between doses
MOA selegiline selectively inhibits MAO-B, increasing availability of DA
use of selegiline adjunctive to l-dopa in parkinsons
toxicityy of selegeliene enhances l-dopa toxicity
MOA sumatriptan 5-HT1D agonist --> vasoconstriction
use of sumatriptan acute migraine cluster headache attacks
what type of drug is bethanechol? direct cholinergic agonist
what type of drug is carbechol direct cholinergic agonist
what type of drug is pilocarpine direct cholinergic agonist
what type of drug is methacholine direct cholinergic agonist
what is the difference between direct cholinergic agonsts and indirect? direct directly stimulate cholinergic receptors and indirect inhibit their breakdown via AChE
uses of bethanechol activates bladder and bowel smooth muscle (used post-op for ileus and urinary retention)
uses of carbechol glaucoma pupillary contraction release of intraocular pressure
uses of pilocarpine potent stimulator for saliva, sweat, and tears
uses of methacholine challenge test for asthma dx
action of methacholine stimulates muscarinic receptors in airway
class: neostigmine indirect cholinomimetic
class pyrodostigmine indirect cholinomimetic
class: edrophonium indirect cholinomimetic
class: physostigmine indirect cholinomimetic
class: echothiophate indirect cholinomimetic
uses for neostigmine post-op and neurogenic ileus and uriNAry retention MG reversal of NM junction blockade
uses for pyridostigmine MG
uses for edrophonium to dx MG
uses for physostigmine glaucoma and atropine OD
uses for echothiophate glaucoma
which indirect ACh agonist penetrates CNS physostigmine
Created by: Asclepius