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Pharm 5

Toxicity of amantadine Ataxia + dizziness+ slurred speech ("Amantadine causes problems with cerebellA")
Two antiviral medications that inhibits influenza neuraminidase, both used for influenza A and B Zanamivir, Oseltamivir
Antiviral - inhibits synthesis of guanine nucleotides by competitively inhibiting IMP dehydrogenase, used for treatment of RSV and chronic hep C Ribavirin
Toxicity for Ribavirin Severe teratogen, Hemolytic anemia
This antiviral medication preferentially inhibits viral DNA polymerase when phosphorylated by viral thymidine kinase Acyclovir
Antiviral medication used for treatment of VZV, HSV, EBV, mucocutaneous and genital herpes lesions, prophylaxis in immunocompromised patients Acyclovir
Toxicity for acyclovir Delirium, Tremor, Nephrotoxicity
Antiviral drug - works by phosphorylation viral kinase, preferentially inhibits CMV DNA polymerase, drug of choice for CMV especialy in immunocopromised patients Ganciclovir
Which drug is more toxic - acyclovir or ganciclovir to host enzymes Ganciclovir
Ganciclovir toxicity Leukopenia, Neutropenia, Thrombocytopenia, Renal toxicity
Viral DNA polymerase inhibitor that binds to the pyrophosphate binding site of the enzyme. Does not require activation by viral kinase FOSCARNET = pyroFOSphate analog
Antiviral drug used for treatment of CMV retinitis in immunocompromised patients when ganciclovir fails FOSCARNET
Patient is on foscarnet for CMV retinitis, which toxicity could be suspected? Nephrotoxicity
Saquinavir, ritonavir, indinavir, nelfinavir, aprenavir - class of drugs HIV therapy, protease inhibitors - inhibit assembly of new virus by blocking protease enzyme
HIV patient is taking anti HIV drugs, develops GI intolerance - nausea, diarrhea, hyperglycemia, lipid abnormalities, thrombocytopenia - which drugs was he taking? PROTEASE INHIBITORS
Zidovudine (AZT), didanosine, zalcitobine, stavudine, lamivudine, abacavir - what class of drugs Reverse transcriptase inhibitors, nucleosides
Name non-nucleosides reverse transcriptase inhibitors Nevirapine, Delavirdine, Efavirenz
Toxicity associated with reverse transcriptase inhibitors Bone marrow suppression (neutropenia, anemia), Peripheral neuropathy, Lactic acidosis (nucleosides), Megaloblastic anemia, Rash (non-nucleosides)
Highly active antiretroviral therapy (HAART) generally entails combination of? Protease inhibitors + reverse transcriptase inhibitors
Which antiretroviral drug is used during pregnancy to reduce risk of fetal transmission AZT
Patient on anti HIV therapy develops megaloblastic anemia - which drug most likely caused it AZT
When is HAART initiated? When patients have low CD4 counts (<500 cell/mm3) or high viral load
Glycoproteins from human leukocytes that block various stages of viral RNA and DNA synthesis, used for treatment of chronic hep B and C, Kaposis sarcoma Name drug and what toxicity associated with it Interferons, Neutropenia
Antiparasitic drug from onchocerciasis Ivermectin (rIVER blindness treated with IVERmectin)
Antiparasitic drug used to treat nematode/roundworm (pinworm, whipworm) infections Mebendazole/thiabendazole
Antiparasitic drugs used to treat giant roundowrm (ascaris), hookworm (Necator/Ancylostoma) and pinworm (Enterobius) Pyrantel pamoate
Antiparasitic used to treat trematode/fluke (shistosomes, Paragonimus, Clonorchis) and cysticercosis Praziquantel
Niclosamide is used to treat? Cestode/tapeworm, infections except cysticercosis
Drug of choice for leishmaniasis Pentavalent antimony
Name anti malaria drugs Chloroquine, Quinine, Mefloquine, Atovaquone, Proguanil
Name drug used for treatment of latent hypnozoite (liver) forms of malaria (Plasmodium vivax, P.ovale) Primaquine
Drug of choice against giardiasis, amoebic dysentery, bacteria vaginitis, Trichomonas Metronidazole
Drug of choice for Chagas disease, American trypanosomiasis (trypanosoma cruzi) Nifurtimox
Drug of choice for African trypanosomiasis (sleeping sickness) Suramin
Cholinomimetic used for postoperative and neurogenic ileus and urinary retention - activates bowel and bladder smooth muscle BETHANECHOL
Direct agonist, cholinomimetic used for treatment of glaucoma, activates ciliary muscle of eye (open angle), pupillary sphincter (narrow angle) Carbachol, pilocarpine
Anticholinesterase, used in treatment of postoperative and neurogenic ileus and urinary retention, myasthenia gravis, reversal of neuromuscular junction blockade (postoperative), increases endogenous Ach Neostigmine
Anticholinesterase used in treatment of myasthenia gravis - increases endogenous Ach, increases strength Pyridostigmine
This anticholinesterase is used for diagnosis of myasthenia gravis (extremely short acting), increases endogenous Ach Edrophonium
Anticholinesterase, used in treatment of glaucoma (crosses BBB to CNS) and atropine overdose, increases endogenous Ach Physostigmine
Anticholinergic, used for treatment of glaucoma, increases endogenous Ach Echothiophate
Name symptoms of cholinesterase inhibitor poisoning (“DUMBBELSS”): Diarrhea, Urination, Miosis, Bronchospasm, Bradycardia, Excitation of skeletal muscle, Lacrimation, Sweating, Salivation (also abdominal cramping)
Name substances that can lead to cholinesterase inhibitor poisoning Parathion and other organophosphates
Antidote used in treatment of organophosphate poisoning Atropine (muscarinic antagonist) plus pralidoxime (chemical antagonist used to regenerate active cholinesterase)
Created by: Asclepius



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