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N112 NSAIDs

N112 - NSAIDs for test 1

QuestionAnswer
NSAIDs Non-steroidal Anti-inflammitory Drugs
First generation NSAIDs inhibit COX 1 & COX 2 enzymes
Second generation NSAIDs inhibit only COX 2 enzyme
Analgesic mild to moderate pain
Anti-inflammatory treatment of musculoskeletal disorders
Anti-pyretic reduction in fever
Platelet aggregation ASA (aspirin) inhibits the COX enzyme in the platelet irreversibly such that the platelet cannon regenerate this enzyme its effect last 7 days
COX 1 enzyme role is to maintain intact GI mucosa; GI (gastrointestinal) side effects are #1 with first generation NSAIDs, also peptic/duodenal ulcers, GI bleeding, nausea, abdominal pain, and indigestion/heartburn
COX 2 enzyme side effects are fatigue, dizziness, lower extremity edema & HTN (hypertension)
Salicylate toxicity or aspirin toxicity symptoms include tinnitus and/or hearing loss
Nursing consideration 1 teach clients to NOT take alcohol & ASA (aspirin) together with NSAIDs
Nursing consideration 2 teach clients to take with full glass of H2O & remain upright for 30 minutes following administration
Nursing consideration 3 advise clients to look for changes in stool (melena or dark/black stools)
Evaluate effectiveness of the drug increased joint mobility, decreased discomfort/pain, fever reduction, reduction in stroke/MI (myocardial infarction)
Drug to drug interactions Alcohol, ASA & anticoagulants, increase GI symptoms, increased bleeding
Created by: jrb265
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