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USMLE

MSK Derm 3

QuestionAnswer
Cause of Green Nail Syndrome P.aeurginosa usually acquired by prolonged exposure to water
Superficial papules and pustules with erythematous halo on parts of body that are covered by shorts Hot Tub Folliculitis
Erythematous macule infarction bullae ulcer; a/w fever, chills, and tenderness in hospitalized/ immunocompromised patients Ecthyma Gangrenosum
Painless ulcer/chancre @ site of inoculation; Hard, clean edge with a yellowish base Primary Syphilis
Firm macules and papules that are pink, brownish-red; Scaly macules on palm; condyloma lata Secondary Syphilis
Plaques and nodules with scars healed in center with/without scales and with/without ulceration Tertiary Syphilis
Jarish-Herxheimer Syndrome Flu-like symptoms within first 24 hours of treatment of syphillis; Normal process caused by lysing of spirochetes
Condyloma acuminatum Verrucae (warts) in genital region
Flat to convex papules with rough, pebble-like surface Verrucae (warts)
Cause of Molluscum Contagiosum poxvirus
Firm, umbilicated (dent in the center), dome- shaped papules, shiny; Pruritic Molluscum Contagiosum
How is latency formed w/ Herpes simplex virus Virus ascends in peripheral sensory nerves and enters dorsal root ganglia where latency is established
Groups of small vesicles and shallow ulcers on erythematous base (pustules erosions crust) Typical herpes lesions
Patches of erythema, small erosions, fissures, or subclinical lesions Atypical herpes lesions
"Dewdrops on a rose petal" Herpes Zoster
Erythematous/Edematous base with superimposed clear vesicles w/ unilateral dermatome distribution Herpes Zoster
Most common dermatophyte infection Trichophyton rubrum
MCC of Tinea Capitas Trichophyton tonsurans
Athlete's foot Tinea Pedis
Dermatophyte infection on scalp Tinea Capitas
Dermatophyte infection on face Tinea Facialis
Dermatophyte infection in inguinal region Tinea Cruris
Dermatophyte infection on trunk/extremities Tinea Corporis
Dermatophyte infection on hand Tinea Manuum
Dermatophyte infection from pets Microsporum canis
sharply demarcated, polycyclic, erythematous, eroded patches with small pustular lesions; base can be scraped away w/ gauze Candidiasis
Cause of Pityriasis (tinea) versicolor Malassezia furfur
Well-demarcated scaling patches with variable pigmentation; Macules that are sharply marginated, round/oval in shape, with varying size Pityriasis (tinea) versicolor
"Spaghetti and meatballs" appearance on KOH stain Pityriasis (tinea) versicolor
Cause of scabies Sarcoptes scabiei mite
Gray/skin-colored ridges from 5mm to 10cm in length Scabies
Cause of Pediculosis The arthropod Phthirus
Hair lice Pediculosis caused by Phthirus Humanus capitas
Genital crabs Pediculosis caused by Phthirus pubis
Tx of Acne vulgarus Tretinoin/Adapalene(retenoids) & Tetracyclines
Tx for Gadolinium induced systemic sclerosis Phototherapy
Topical agent used to treat S. aureus and most Strep except group D Mupirocin
Topical agent used to treat dermatophyte infections Griseofulvin
Topical/oral agent used to treat dermatophyte infections Terbinafine (an allylamine)
Topical agent that is very effective on yeasts Nystatin
Tx of ectoparasites Permethrin (preferred tx) & Lindane (not used as much due to neurotoxicity)
Tx of psoriasis Methotrexate(antimetabolite) & Cyclosporin (Calcineurin inhibitor)
Topical Tx of actinic keratosis, Bowens disease and superficial basal cell carcinoma 5-fluorouracil
Tx of atopic dermatitis Tacrolimus & Pimecrolimus(mild to moderate cases) Both are calcineurin inhibitors
Patients on Calcineurin inhibitors must do what? Wear sunscreen when outside due to cutaneous immunosuppresion that could lead to skin cancer
Biological agent that binds 2 molecules of TNF Etanercept
Biological agent that binds to the TNF receptor Infliximab
MCC of dwarfism Achondroplasia
Cause of Achondroplasia defect in a fibroblast growth factor receptor protein (FGFR3) Found on chrom 4
MCC of osteomyelitis S. aureus
MCC of osteomyelitis a/w GU infections E. Coli, Pseudomonas, Klebsiella
MCC of osteomyelitis a/w drug abuse E. Coli, Pseudomonas, Klebsiella
MCC of osteomyelitis in neonates H. Influenzae and Group B Strep
MCC of osteomyelitis in pt's w/ sickle cell disease Salmonella
Pott's disease Tuberculosis osteomyelitis involving the spine
Muscle disease w/ LMN signs Poliomyelitis
Muscle disease w/ both UMN & LMN signs Amyotrophic lateral Sclerosis
Muscle disease seen in infants ("floppy baby") Werdnig-Hoffmann disease
Symmetric ascending muscle weakness beginning in distal and lower extremities Guillain-Barre Disease
Genetics of Duchenne Muscular Dystrophy X-linked recessive Complete absence of dystrophin gene
Genetics of Becker’s Muscular Dystrophy X-linked recessive Mutation causing production of truncated dystrophin
Defect in Oculopharyngeal dystrophy PABPN1(Poly-A binding protein, nuclear 1) gene on chrom 14 GCG trinucleotide expansion
Defect in limb-girdle dystrophy Mutation of laminin
Defect in Emery-dreifuss dystrophy Mutation of emerin(X-linked) Less commonly, mutation of laminin
Defect in myotonic dystrophy DMPK (dystrophila myotonia-protein kinase) gene on chrom 19 CTG trinucleotide expansion
Defect in Nemaline myopathy ACTA 1 gene on chrom 1; threadlike; dark inclusions of Z-band material in type I fibers
Defect in Central Core Disease RYR 1 gene on chrom 19; codes for a calcium release channel; a/w malignant hyperthermia
Kearns-Sayre Syndrome Ophthalmoplegia plus retinal pigmentary degeneration and complete heart block Caused by large deletion of mitochondrial DNA
Dermatomyositis Heliotrope rash with periorbital edema; Muscle weakness; myocarditis; interstitial lung dx, 40% have cancer too
Created by: Asclepius