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USMLE

MSK Derm 2

QuestionAnswer
What layer of skin does bullous pemphigoid affect? Subepidermal blisters
What layer of skin does impetigo affect? Subcorneal blisters
What layer of skin does pemphigus vulgaris affect? Intraepidermal blisters
What layer of skin does eczema affect? Intraepidermal blisters
What layer of skin does dermatitis herpetiformis affect? Subepidermal blisters
Flat circumscribed lesion less than 5 mm in diameter Macule
Flat circumscribed lesion more than 5 mm in diameter Patch
Elevated lesion less than 5 mm in diameter Papule
Elevated lesion with spherical contour greater than 5 mm in diameter Nodule
Elevated flat-topped lesion, usually greater than 5 mm in diameter Plaque
Fluid-filled raised lesion less than 5 mm in diameter Vesicle
Fluid-filled raised lesion greater than 5 mm in diameter Bulla
Common term used for vesicle or bulla Blister
Discrete, pus-filled, raised lesion Pustule
Itchy, transient, elevated lesion with variable blanching and erythema Wheal
Dry, horny, platelike excrescence Scale
Thickened and rough skin characterized by prominent skin markings Lichenification
Dried exudates from vesicle, bulla, or pustule; over superficial shallow erosions Crust
Traumatic lesion characterized by breakage of the epidermis, causing a raw linear area Excoriation
Separation of nail plate from nail bed Onycholysis
Thickening of the stratum corneum Hyperkeratosis
A break in the skin, usually where it joins a mucous membrane, producing a crack-like sore or ulcer Fissure
Modes of keratinization characterized by the retention of the nuclei in the stratum corneum Parakeratosis
Hyperplasia of the stratum granulosum Hypergranulosis
Diffuse epidermal hyperplasia Acanthosis
Surface elevation caused by hyperplasia and enlargement of contiguous dermal papillae Papillomatosis
Abnormal keratinization occurring prematurely within individual cells or groups of cells below the stratum granulosum Dyskeratosis
Loss of intercellular connections resulting in loss of cohesion between keratinocytes Acantholysis
Intercellular edema of the epidermis Spongiosis
Intracellular edema of keratinocytes Hydropic swelling
Infiltration of the epidermis by inflammatory or circulating blood cells Exocytosis
Discontinuity of the skin exhibiting incomplete loss of the epidermis Erosion
Discontinuity of the skin exhibiting complete loss of the epidermis and often of portions of the dermis and even subcutaneous fat Ulceration
Formation of vacuoles within or adjacent to cells Vacuolization
Referring to a linear pattern of melanocyte proliferation within the epidermal basal cell layer Lentiginous
What is normal transepidermal water loss? 150 mL/day
How does TEWL change after loss of the stratum corneum? TEWL increases by a factor of 50
Genetics of Dysplastic nevi syndrome Autosomal dominant Involves genes on chrom 1, 9 or 12
Genetics of Basal cell nevus syndrome Autosomal dominant Mutated ptc gene on chrom 9q22
Epidermodysplasia veruciformis is a/w what? HPV types 5 & 8
Flat, red warts all over the skin; genitals are usually spared Epidermodysplasia veruciformis
Disorder characterized by blister formation in response to mechanical trauma Epidermolysis bullosa
Nevi that are larger than normal and may occur as hundreds of lesions on the body Dysplastic nevi syndrome
Skin cancer w/ windblown histologic appearance Squamous cell carcinoma
Skin cancer w/ pink, amorphous areas because of keratin production Squamous cell carcinoma
Bowen's syndrome Squamous cell carcinoma in situ
Most common skin cancer Basal cell carcinoma
Skin cancer w/ basophilic staining Basal cell carcinoma
Skin cancer w/ Peripheral palisading Basal cell carcinoma
Skin cancer w/ bcl-2, α-SMA & Stromolysin 3 mutations Basal cell carcinoma
Least common skin cancer Melanoma
Most common type of melanoma Superficial spreading melanoma
Rarest type of melanoma Nodular melanoma
Clark staging based on level of invasion levels 1-5
Breslow staging based on thickness of lesion <.75mm= good prognosis Best prognostic indicator
Erythematous macule leading to multiple small pustules; rupture and ULCERATE with thick crust Ecthyma Usually a neglected impetigo that progresses
Erythematous macule leading to multiple small pustules; rupture and FORM EROSIONS covered in crust Impetigo
Acute, deep-seated, red, hot, tender nodule or abscess Furuncle
Deeper infection (than furncle) comprised of interconnecting abscesses usually arising in several contiguous hair follicles Carbuncle
Crops of small pustules centered around hair shaft, erythema Folliculitis
Cause of Erysipelas group A β-hemolytic streptococci
Cause of Cellulitis Staphylococcus aureus
Red, hot, edematous and shiny plaque that may contain vesicles, bullae, erosions or abscesses Erysipelas (defined boders) & Cellulitis (ill-defined borders)
Cause of Erythrasma Corynebacterium minutissimum
Sharply marginated macule; scaling, erosion, fissure can occur Erythrasma
Shows a coral-red fluorescence w/ Wood's lamp Erythrasma
Cause of Pitted Keratolysis Micrococcus sedentarius
Pits in stratum corneum; Sometimes discrete, oftentimes large areas of eroded corneum form; white when hydrated Pitted Keratolysis
Created by: Asclepius