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USMLE

Repro Path 2

QuestionAnswer
Which CIN is considered carcinoma in situ? CIN-3
what type of CA is assoc w/ cervix? what is the Cause Of Death in 80% of patients? Squamous cell CA COD: UREMIA due to local extension to compress ureters
Definition: Endometriosis in the myometrium Adenomyosis
MC GYN malignancy what is presenting age range? Endometrial CA age: 55-65
Dx: Bulky tumor w/ areas of necrosis and hemorrhage, typically arising de novo, may protrude from cervix and bleed Leiomyosarcoma
Ovarian Cyst: distention of unruptured graafian follicle; may be assoc w/ hyperestrinism and endometrial hyperplasia Follicular cyst
Ovarian Cyst: hemorrhage into persistent corpus luteum; mentrual irregularities Corpus Luteum cyst
Ovarian Cyst: bilateral, multiple, due to gonadotropin stimulation; can be assoc w/ choriocarcinoma or hydatidiform moles Theca-Lutein cyst
Ovarian Cyst: blood-containing cyst from ovarian endometriosis; varies w/ mentrual cycle Chocolate cyst
Dx: amenorrhea, infertility, obesity, hirsutism, multiple small follicular cysts what hormone is in excess? Polycystic Ovarian syndrome Increased LH
Dx: frequently bilateral, lined w/ fallopian tube-like epithelium, benign; Serous Cystadenoma (20% of ovarian tumors)
Dx: frequently bilateral, malignant, w/ fallopian tube-like epithelium; 50% of ovarian tumors Serous Cystadenocarcinoma
Dx: multilocular cyst lined by mucus-secreting epithelium; benign Mucinous Cystadenoma
Dx: malignant tumor w/ mucus-secreting epithelium, can rupture producing multiple peritoneal tumor implants that produce mucinous material Mucinous Cystadenocarcinoma
Definition: Rupture of a mucinous tumor that causes multiple peritoneal tumor implants, all producing large quantities of intraperitoneal mucinous material Pseudomyxoma Peritonei
Dx: benign ovarian tumor that resembles Bladder transitional epithelium Brenner tumor [Brenner = Bladder]
Dx: Ovarian tumor w/ bundles of spindle-shaped fibroblasts what cell does it originate from? Ovarian Fibroma (Thecal cell)
Dx: Ovarian fibroma, ascites, hydrothorax Meigs syndrome
Dx: ovarian estrogen-secreting tumor causing precocious puberty in kids or endometrial hyperplasia in adults. name and describe the characteristic cell Granulosa cell tumor Call-Exner bodies: small follicles filled w/ eosinophilic secretions
Dx: MC malignant germ cell tumor of the ovary; sheets of uniform cells w/ Inc hCG Dysgerminoma (Seminoma in man)
Dx: aggressive malignancy in ovaries, produces alpha-fetoprotein, Schiller-Duval bodies Endodermal Sinus (Yolk Sac) tumor
Dx: rare, malignant ovarian tumor that can develop during pregnancy in mother or baby; large hyperchromatic syncytiotrophoblastic cells; high b-hCG Choriocarcinoma
MC benign ovarian tumor name and describe what it can contain? Teratoma Stuma Ovarii - functional thyroid tissue
In females, how does the Immature vs Mature teratoma differ from Males? Females: Immature - aggressively Malignant Mature - Benign (Men Mature are Malignant)
MC testicular CA in older men Testicular lymphoma
Dx: aggressive malignant neoplasm w/ Inc hCG and early spread to lungs; preceded by hydatidiform mole, abortion of ectopic or normal pregnancy Gestational Choriocarcinoma (more common then Ovarian type)
MC disorder of the breast b/t 25 - 50 yo It may present w/ what characteristic? Fibrocystic Dz (Blue dome cyst)
Dx: diffuse breast pain w/ fibrosis and multiple lesions bilaterally what type has cellular atypia of small ducts w/ fibrosis? Fibrocystic Dz (Sclerosing Adenosis)
MC benign breast tumor in women < 25 yo Fibroadenoma
Dx: small, benign, firm, rubbery, painless, well-circuscribed lesion of breast Fibroadenoma (less then 25 yo)
Dx: benign large bulky mass of connective tissue and cysts in breast; has "leaflike" projections Cystosarcoma Phyllodes
Dx: tumor of lactiferous duct, presenting w/ serous or bloody nipple discharge Intraductal papilloma
What receptors are expressed in post-menopausal malignant CA of breast? (2) Overexpression of E2/P4 receptors erb-B2 (HER-2)
MC place for Malignant breast CA Upper, outer quadrant
Dx: eczematous patches on nipple, characteristic large cells surrounded by clear halo area, invades epidermis, underlying ductal CA always present Padget Dz of the Breast
Dx: malignant breast CA w/ Lymphocytic infiltrate Medullary CA
Dx: multicentric or Bilateral breast CA w/ cells arranged in linear ("indian-file") fashion Invasive Lobular CA [Invasive Lobular = Indian Line]
Dx: breast CA w/ lymphatic involvement of skin by underlying CA causing red, swollen and hot area on breast Inflammatory CA
Dx: tumor cells fill breast ducts resulting in necrosis and a cheese-like consistency (2 names) Intraductal CA in situ (Comedocarcinoma) [Cheesy Comedian]
Dx: malignant breast CA w/ tumor cells in cords, islands and glands embedded in dense fibrous stroma; firm consistency Invasive Ductal CA (MC malignant Breast CA)
Dx: clusters of neoplastic cells fill intralobular ductules and acini and don't pass BM, often metastasis to bilateral breast by time of initial Dx Lobular CA in situ
Dx: malignant breast CA w/ pools of extracellular mucus surrounding clusters of tumor cells; gelatinous consistency Mucinous (Colloid) CA
Dx: young adult w/ fever, vomiting and diarrhea, rapid pulse and hypotension, diffuse macular rash Toxic Shock syndrome (S. aureus)
what bug causes PID in combo w/ monoarticular arthritis? Gonorrhea
Created by: Asclepius