Help
Options
Didn't know it?
click below
click below
Knew it?
click below
click below
Don't Know
Remaining cards (0)
Know
retry
shuffle
restart
0:00
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.
Normal Size Small Size show me how
Normal Size Small Size show me how
MICABI - Exam 1
oxazolidinon and streptogramins (last of macrolide lecture)
| Question | Answer |
|---|---|
| first commericially available oxazolidinone antibiotic | linezolid |
| linezolid mechanism of action | binds 23S portion of 50S subunit close to the peptidyl transferase and chloramphenicol binding sites; stops 30S and 50S from binding together - prevents protein synthesis |
| linezolid spectrum | gram-positive bacteria and some Gram-negative anaerobic species (no Gram-neg aerobes) Multi-drug resistant organisms such as MRSA, staphyl with reduced susceptibility to vancomycin, penicillin- and macrolide-resistant pneumococci and VRE fully susceptible |
| linezolid clinical use | save it for the nasty stuff - usually reserved for the treatment of serious bacterial infections where older antibiotics have failed due to antibiotic resistance; skin infections or nosocomial pneumonia with methicillin/penicillin resistance |
| linezolid PK | almost 100% bioavailability; AUC almost identical after oral and iv. administration |
| linezolid SEs | Thrombocytopenia in use for longer than 2 weeks; is a MAOI and can't be used with tyramine containing foods or pseudoephedrine |
| group of natural cyclic peptides produced by bacteria, consists of two structurally unrelated molecules | streptogramins |
| strepogramins mechanism of action | bind to distinct sites on the 50S ribosomal subunit. Cooperate to inhibit protein synthesis |
| Synercid | Quinupristin/dalfopristin - streptogramin approved by FDA |
| Streptogramin spectrum (general) | Active against most gram positive bacteria and most respiratory pathogens including pneumococci, Mycoplasma pneumoniae, Legionella pneumophilia, Chlamydia pneumoniae |
| Streptogramin spectrum (special) | 90% of Staph. aureus and coagulase negative staphylococci including MR strains; pencillin resistant pneumococci; Enterococcus faecium including strains which are resistant to ampicillin, gentamicin and vancomycin. Not active against E. faecalis |
| Streptogramin metabolism (Quinupristin/dalfopristin - Synercid) | metabolized by liver and excreted in bile |
| Streptogramin SEs | infusion site reactions |
| streptogramin interactions | potent CYP3A4 inhibitor |
| Streptogramin clinical use | bacteremia and life-threatening infection caused by vancomycin-resistant Enterococcus faecium (VREF); complicated skin structure infection caused by Staphylococcus aureus and Streptococcus pyogenes |
Created by:
Krafty
Popular Science sets