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what is the triad associated with Wegener's granulomatosis? necrotizing vasculitis, necrotizing granulomas in the lung and upper airway, and necrotizing glomerulonephritis
perforation of nasal septum, chronic sinusitis, otitis media, mastoiditis, cough, dyspnea, hemoptysis, and hematuria are associated with what disease? Wegener's granulomatosis
what is a strong marker of Wegener's granulomatosis? C-ANCA
what might be seen on chest x ray in Wegener's? large nodular densities
what is the treatment for Wegener's? cyclophosphamide and corticosteroids
this vasculitide is like Wegener's but lacks granulomas and is associated with P- or C-ANCA microscopic polyangitis
this is a vasculitis limited to the kidney primary pauci-immune crescentic glomerulonephritis
granulomatous vasculitis with eosinophilia that involves lungs, heart, skin, kidneys, nervous system; often seen in atopic patients Churg-Strauss syndrome
this is an acute, self-limiting disease of infants/kids; acute necrotizing vasculitis of small/medium sized vessels; fever, congested conjunctiva, changes in lips/oral mucosa, lymphadenitis Kawasaki disease/ mucocutaneous lymph node syndrome
what potentially serious outcome can result from Kawakaki disease? coronary aneurysms
what is the most common form of childhood systemic vasculitis? Henoch-Schonlein purpura
skin rash, arthralgia, intestinal hemorrhage, abdominal pain, and melena in kid? Henoch-Schonlein purpura
where do giant cell bone tumors most commonly occur? in what age group? epiphyseal end of long bones - 20-40 years old
this is a locally aggressive benign tumor often around the distal femur, proximal tibial region giant cell tumor
what type of bone tumor has a 'soap bubble' or 'double bubble' appearance on x-ray? giant cell tumor
spindle-shaped cells with multinucleated giant cells found in what type of benign bone tumor? giant cell tumor
what is the most common benign bone tumor? osteochondroma (exostosis)
this type of bone tumor is usually found in men <25 and commonly originates from long metaphysis osteochondroma
this is a benign cartilaginous neoplasm found in intramedullary bone, usually in the distal extremities endochondroma
what is the most common malignant tumor of bone? osteosarcoma
this malignant bone tumor's peak incidence is in men 10-20 years old and is commonly found in the metaphysis of long bones osteosarcoma
name some predisposing factors for osteosarcoma Paget's disease of bone, bone infarcts, radiation, and familial retinoblastoma
what organism causes scalded skin syndrome? staph
how do you distinguish pemphigus vulgaris from bullous pepmphigoid? pemphigus vulgaris is associated with oral ulcers
atuoantibody directed against transmembrane cadherin adhesion molecules induces acantholysis (breakdown of epithelial cell-cell connections) with resulting intraepidermal blister formation pemphigus vulgaris
molluscum contagiosum is related to infection with what virus? poxvirus
honey-brown crusted lesions in various stages? what organism? impetigo - strep pyogenes or staph aureus; distinguish by catalase test
autoimmune attack on hair follicles alopecia areata
androgenic alopecia common male pattern baldness
fine, nonblotchy truncal rash in a not-very-ill kid with no Koplik spots rubella
target lesions erythema multiforme
granular complement and IgG at the dermal-epidermal junction rash biopsy in SLE
biopsy of xanthomas shows what? multinucleated giant cells
Created by: Asclepius