Busy. Please wait.

show password
Forgot Password?

Don't have an account?  Sign up 

Username is available taken
show password


Make sure to remember your password. If you forget it there is no way for StudyStack to send you a reset link. You would need to create a new account.
We do not share your email address with others. It is only used to allow you to reset your password. For details read our Privacy Policy and Terms of Service.

Already a StudyStack user? Log In

Reset Password
Enter the associated with your account, and we'll email you a link to reset your password.
Don't know
remaining cards
To flip the current card, click it or press the Spacebar key.  To move the current card to one of the three colored boxes, click on the box.  You may also press the UP ARROW key to move the card to the "Know" box, the DOWN ARROW key to move the card to the "Don't know" box, or the RIGHT ARROW key to move the card to the Remaining box.  You may also click on the card displayed in any of the three boxes to bring that card back to the center.

Pass complete!

"Know" box contains:
Time elapsed:
restart all cards
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.

  Normal Size     Small Size show me how


MSK 1 (pharm)

what is the mechanism of opiod analgesics? act as agonists at opiod receptors to modulate synaptic transmission
what opiod works at the mu receptor? morphine
what opiod works at the delta receptor? enkephalin
what opoid workds at the kappa receptor? dynorphin
how do you treat opiod toxicity? naloxone or naltrexone (opiod receptor antagonists)
what is contraindicated in morphine overdose? O2 - might contribute to respiratory failure
toxicity of opiods? respiratory depression, miosis (pinpoint pupils), additive CNS depression with other drugs, constipation, addiction
how do NSAIDs work? reversibly inhibit COX-1 and COX-2; block prostaglandin synthesis
what is used to close a PDA? indomethacin
toxicity of NSAIDs? renal damage, aplastic anemia, GI distress, ulcers
how do celecoxib, valdecoxib work? selectively inhibit COX-2, which is found in inflammatory cells and mediates inflammation and pain
why should COX 2 inhibitors not have the corrosive effects of other NSAIDs on the GI lining? spares COX-1, which helps maintain the gastric mucosa
what are COX 2 inhibitors used for? rheumatoid and osteoarthritis
what is the mechanism of acetominaphen? reversibly inhibits cyclooxygenase, mostly in CNS; inactivated peripherally
what is the antidote for acetominaphen toxicity? N-acetylcysteine
what drug is used for acute gout? colchicine
this gout drug depolymerizes microtubules, impairing leukocyte chemotaxis and degranulation colchicine
what acute gout drug is less toxic than colchicine and therefore is used more frequently? indomethacin
this drug is used for chronic gout - it inhibits resorption of uric acid probenecid
what gout drug inhibits secretion of penicillin? probenecid
what is the mechanism of allopurinol? what is it used for? inhibits xanthine oxidase, decreasing conversion of xanthine to uric acid; used for chronic gout (when under control)
what gout drug is also used in lymphoma and leukemia to revent tumor lysis-associated nephropathy? allopurinol
what is etanercept? recombinant form of human TNF receptor that binds TNF-alpha
what is etanercept used for? RA, psoriasis, ankylosing spondylitis
what is infliximab? TNF-alpha antibody
what is infliximab used for? Crohn's disease, RA, ankylosing spondylitis
this drug binds to cyclophilins, and the complex blocks the differentiation and activation of T cells by inhibiting calcineurin, thus preventing production of IL-2 and its receptor cyclosporine
when is cyclosporine used? suppresses organ rejection after transplantation; selected AI disorders
the nephrotoxicity associated with cyclosporine is preventable with what? mannitol diuresis
what toxicity is associated with cyclosporine? predisposes to viral infections and lymphoma
what is the mechanism of action of tacrolimus (FK-506)? what drug is it similar to? binds to FK-binding protein, inhibiting secretion of IL-2 and other cytokines; similar in action to cyclosporine
what is tacrolimus used for? potent immunosuppressive used in organ transplant recipients
what toxicities are associated with tacrolimus? significant nephrotoxicity, peripheral neuropathy, hypertension, pleural effusion, hyperglycemia
this drug is an antimetabolite derivative of 6-mercaptopurine that interferes with the metabolism and synthesis of nucleic acids; it is toxic to proliferating lymphocytes azathioprine
when is azathioprine used? kidney transplants; AI disorders including glomerulonephritis and hemolytic anemia
toxic effects of this drug may be increased by allopurinol azathioprine - active metabolite mercaptopurine is metabolized by xanthine oxidase
what is the major toxicity associated with azathioprine? bone marrow suppression
acetomeniphen metabolite depletes what in the liver? glutahione and forms toxic tissue adducts
low doses of uricosuric agents and salicylates do what to the serum uric acid concentration? increase it
what type of ossification is not affected in achondroplasia? membranous - skull, facial bones, and axial skeleton are normal
Created by: Asclepius