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USMLE
Cell Bio/Histo/Path -6
| Question | Answer |
|---|---|
| Association for tumor marker: PSA | Screening for Prostatic Carcinoma |
| Association for tumor marker: CEA | -Carcinoembryonic antigen. -In ~70% of colorrectal and pancreatic cancers -Also produced by gastric and breast carcinomas -Very nonspecific |
| Association for tumor marker: alpha-fetoprotein | -Hepatocellular carcinomas -Nonseminomatous germ cell tumors of the testis (eg yolk sac tumor) |
| Association for tumor marker: beta-hCG | -Hydatidiform moles -Choriocarcinomas -Gestational trophoblastic tumors |
| Association for tumor marker: CA-125 | Ovarian malignant epithelial tumors |
| Association for tumor marker: S-100 | -Melanoma -Neural tumors -Astrocytomas |
| Association for tumor marker: Alkaline phosphatase | -Metastases to bone -Obstructive biliary disease -Paget's disease of bone |
| Association for tumor marker: Bombesin | -Neuroblastoma -Lung cancer -Gastric cancer |
| Association for tumor marker: TRAP | -Tartrate-resistance acid phosphatase -Found in hairy cell leukemia |
| What type of cell is found in hairy cell leukemia? | B-cells |
| Association for tumor marker: CA-19-9 | Pancreatic adenocarcinoma |
| Tumor marker for: Prostatic carcinoma | -PSA -Prostatic acid phosphatase |
| Tumor marker for: Colorectal cancer | CEA - Carcinoembryonic antigen -Produced by 70% of colorectal cancers |
| Tumor marker for: Pancreatic cancer | CEA - Carcinoembryonic antigen -Produced by 70% of pancreatic cancers CA-19-9 -Produced in pancreatic adenocarcinoma |
| Tumor marker for: Gastric carcinoma | -CEA - Carcinoembryonic antigen -Bombesin |
| Tumor marker for: Breast carcinoma | CEA - Carcinoembryonic antigen |
| Tumor marker for: Hepatocellular carcinoma | alpha-fetoprotein |
| Tumor marker for: Nonseminomatous germ cell tumors of the testis | alpha-fetoprotein |
| Tumor marker for: Hydatidiform moles | beta-hCG |
| Tumor marker for: Choriocarcinoma | beta-hCG |
| Tumor marker for: Gestational Trophoblastic tumors | beta-hCG |
| Tumor marker for: Malignant ovarian epithelial tumors | CA-125 |
| Tumor marker for: Melanoma | S-100 |
| Tumor marker for: Neural tumors | General: S-100 Neuroblastoma: Bombesin |
| Tumor marker for: Astrocytomas | S-100 |
| Tumor marker for: Metastases to bone | Alkaline phosphatase |
| Tumor marker for: Obstructive biliary disease | Alkaline phosphatase |
| Tumor marker for: Paget's disease of bone | Alkaline phosphatase |
| Tumor marker for: Neuroblastoma | Bombesin |
| Tumor marker for: Lung cancer | Bombesin |
| Tumor marker for: Hairy cell leukemia | TRAP (Tartrate-resistant acid phosphatase) |
| Tumor marker for: Pancreatic adenocarcinoma | CA-19-9 |
| Cancer associated with: HTLV-1 | HTLV=Human T-Lymphotropic Virus Adult T-cell leukemia |
| Cancer associated with: HBV | Hepatocellular carcinoma |
| Cancer associated with: HCV | Hepatocellular carcinoma |
| Cancer associated with: EBV | -Burkitt's lymphoma -Nasopharyngeal carcinoma |
| Cancer associated with: HPV | -Cervical carcinoma (with HPV 16,18) -Penile/anal carcinoma |
| Cancer associated with: HHV-8 | HHV-8 = Kaposi's sarcoma-associated herpes virus -Kaposi's sarcoma -body cavity fluid B-cell lymphoma |
| Oncogenic virus associated with: Adult T-cell leukemia | HTLV-1 (HTLV=Human T-Lymphotropic Virus) |
| Oncogenic virus associated with: Hepatocellular carcinoma | -HBV -HCV |
| Oncogenic virus associated with: Burkitt's lymphoma | EBV |
| Oncogenic virus associated with: Nasopharyngeal carcinoma | EBV |
| Oncogenic virus associated with: Cervical carcinoma | HPV 16 and 18 |
| Oncogenic virus associated with: Penile carcinoma | HPV |
| Oncogenic virus associated with: Anal carcinoma | HPV |
| Oncogenic virus associated with: Kaposi's sarcoma | HHV-8 (aka Kaposi's sarcoma-associated herpesvirus) |
| Oncogenic virus associated with: body cavity fluid B-cell lymphoma | HHV-8 (Human Herpesvirus 8) |
| Organ affected by: Aflatoxins | Liver (hepatocellular carcinoma) |
| Organ affected by: Vinyl chloride | Liver (angiosarcoma) |
| Organ affected by and effects of: CCl4 | Liver -centrilobular necrosis -fatty change |
| Organ affected by: Nitrosamines | -Esophagus -Stomach |
| Organ affected by: Cigarette smoke | -Larynx -Lung |
| Organ affected by: Asbestos | Lung -Mesothelioma -Bronchogenic carcinoma |
| Organ affected by: Arsenic | Skin (squamous cell carcinoma) |
| Organ affected by: Naphthalene (aniline) dyes | Bladder (transitional cell carcinoma) |
| Organ affected by: Alkylating agents | Blood (leukemia) |
Created by:
Asclepius
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