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USMLE
Cell Bio/Histo/Path -5
Question | Answer |
---|---|
Gene associated with this tumor: CML | oncogene abl (philadelphia chromosome) |
Gene associated with this tumor: Burkitt's lymphoma | oncogene c-myc |
Gene associated with this tumor: Follicular lymphoma | oncogene bcl-2 (inhibits apoptosis) |
Gene associated with this tumor: Undifferentiated lymphoma | oncogene bcl-2 (inhibits apoptosis) |
Gene associated with this tumor: Breast carcinoma | oncogene erb-B2 |
Gene associated with this tumor: Ovarian carcinoma | oncogene erb-B2 |
Gene associated with this tumor: Gastric carcinoma | oncogene erb-B2 |
Gene associated with this tumor: Colon carcinoma | oncogene ras |
Gene associated with this tumor: Lung tumor | oncogene L-myc (L for Lung) |
Gene associated with this tumor: Neuroblastoma | oncogene N-myc (N for neuroblastoma) |
Gene associated with this tumor: Multiple Endocrine Neoplasia type I | oncogene MEN1 encoding menin on chromosome 11q |
Gene associated with this tumor: Multiple Endocrine Neoplasia type II | oncogene ret |
Gene associated with this tumor: Multiple Endocrine Neoplasia type III | oncogene ret |
Chromosome and tumor associated with this gene (what type of gene): Rb | Tumor suppressor gene on 13q: Retinoblastoma, osteosarcoma |
Chromosome and tumor associated with this gene (what type of gene): BRCA1 | Tumor suppressor gene on 17q: Breast and ovarian cancer |
Chromosome and tumor associated with this gene (what type of gene): BRCA2 | Tumor suppressor gene on 13q: Breast and ovarian cancer |
Chromosome and tumor associated with this gene (what type of gene): p53 | Tumor suppressor gene on 17p: Most human cancers and Li-Fraumeni Syndrome |
Chromosome and tumor associated with this gene (what type of gene): p16 | Tumor suppressor gene on 9p: Melanoma |
Chromosome and tumor associated with this gene (what type of gene): APC | Tumor suppressor gene on 5q: Colorectal cancer |
Chromosome and tumor associated with this gene (what type of gene): WT1 | Tumor suppressor gene on 11q: Wilm's tumor |
Chromosome and tumor associated with this gene (what type of gene): NF1 | Tumor suppressor gene on 17q: Neurofibromatosis type 1 |
Chromosome and tumor associated with this gene (what type of gene): NF2 | Tumor suppressor gene on 22q: Neurofibromatosis type 2 |
Chromosome and tumor associated with this gene (what type of gene): DPC | Tumor suppressor gene on 18q: Pancreatic cancer |
Chromosome and tumor associated with this gene (what type of gene): DCC | Tumor suppressor gene on 18q: Colon cancer |
Gene and associated tumor on chromosome: 5q | Tumor suppressor gene APC: Colorectal cancer |
Gene and associated tumor on chromosome: 9p | Tumor suppressor gene p16: melanoma |
Gene and associated tumor on chromosome: 11q | Tumor suppressor gene WT1: Wilm's tumor |
Gene and associated tumor on chromosome: 13q | Tumor suppressor genes Rb (Retinoblastoma, Osteosarcoma) and BRCA2 (Breast and Ovarian cancer) |
Gene and associated tumor on chromosome: 17p | Tumor suppressor gene p53: Most human cancers and Li-Fraumeni syndrome |
Gene and associated tumor on chromosome: 17q | Tumor suppressor genes BRCA1 (Breast and ovarian cancer) and NF1 (Neurofibromatosis type 1) |
Gene and associated tumor on chromosome: 18q | Tumor suppressor genes DPC (Pancreatic cancer) and DCC (Colon cancer) |
Gene and associated tumor on chromosome: 22q | Tumor suppressor gene NF2: Neurofibromatosis type 2 |
Gene and matching chromosome associated with: Retinoblastoma | Tumor suppressor gene Rb on chromosome 13q |
Gene and matching chromosome associated with: Osteosarcoma | Tumor suppressor gene Rb on chromosome 13q |
Gene and matching chromosome associated with: Breast cancer | Tumor suppressor genes BRCA1 (17q) and BRCA2 (13q) |
Gene and matching chromosome associated with: Ovarian cancer | Tumor suppressor genes BRCA1 (17q) and BRCA2 (13q) |
Gene and matching chromosome associated with: Most human cancers | Tumor suppressor gene p53 on chromosome 17p |
Gene and matching chromosome associated with: Li-Fraumeni syndrome | Tumor suppressor gene p53 on chromosome 17p |
Gene and matching chromosome associated with: Melanoma | Tumor suppressor gene p16 on chromosome 9p |
Gene and matching chromosome associated with: Colorectal cancer | Tumor suppressor gene APC on chromosome 5q |
Gene and matching chromosome associated with: Wilms' tumor | Tumor suppressor gene WT1 on chromosome 11q |
Gene and matching chromosome associated with: Neurofibromatosis type 1 | Tumor suppressor gene NF1 on chromosome 17q |
Gene and matching chromosome associated with: Neurofibromatosis type 2 | Tumor suppressor gene NF2 on chromosome 22q |
Gene and matching chromosome associated with: Pancreatic cancer | Tumor suppressor gene DPC on chromosome 18q |
Gene and matching chromosome associated with: Colon cancer | Tumor suppressor gene DCC on chromosome 18q |
Oncogenes: gain or loss of function QUICK | onco: gain |
tumor suppressor genes: gain or loss of function QUICK | tumor suppressor: loss |
Oncogenes: one or two alleles need to be damaged QUICK | One (gain of function) |
Tumor suppressor genes: one or two alleles need to be damaged QUICK | Two (loss of function) |