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USMLE

Real Immuno 6 - Dzs by Hypersensitivity

QuestionAnswer
allergic rhinitis & anaphylaxis type I
hemolytic anemia type II
idiopathic thrombocytopenic purpura type II
erythroblastosis fetalis type II
rheumatic fever type II
Goodpasture's syndrome type II
bullous pemphigoid type II
Graves' dz type II
myasthenia gravis type II
SLE type III
rheumatoid arthritis type III
polyarteritis nodosum type III
post-strep glomerulonephritis type III
serum sickness type III
arthus reaction type III
hypersensitivity pneumonitis type III
type I diabetes mellitus type IV
multiple sclerosis type IV
Guillain-Barre syndrome type IV
Hashimoto thyroiditis type IV
Graft vs Host dz type IV
PPD (TB test) type IV
contact dermatitis type IV
IgM, IgG bind to Ag on "enemy" cell--> lysis or phagocytosis type II (Ab-mediated)
Ag-Ab complexes activate complement which attracts PMNs who release dangerous substances type III (immune complex)
sensitized T cells encounter Ag and release lymphokines to activate macrophages type IV (delayed)
fever, urticaria, arthralgias, proteinuria, lymphadenopathy 5-10 days after Ag exposure (serum sickness) type III
Created by: Asclepius