click below
click below
Normal Size Small Size show me how
USMLE
Real Immuno 4
Question | Answer |
---|---|
What does terminal deoxynucleotidyl transferase do? | Addition of nucleotides to DNA during "genetic recombination" in B cells |
What does Tdt stand for? | Terminal deoxynucleotidyl transferase |
Which immunoglobulins are expressed on the surface of mature B cells? | IgM and IgD |
What is isotype switching? | Differentiation of B cells into plasma cells that secrete IgG, IgA, or IgE |
What stimulates isotype switching? | Cytokines (IL-4 and IL-5) and CD40-Ligand on T-cells |
Main antibody isotype in secondary immune response | IgG |
Most abundant antibody isotype | IgG |
Antibody isotypes which cross placenta | IgG |
Antibody isotypes which fix complement | IgG and IgM in the classic complement pathway Mnemonic: GM makes classic cars |
Antibody isotypes which opsonize bacteria | IgG (and IgA weakly) |
Main antibody isotype in primary immune response | IgM |
Antibody isotypes associated with the J chain | IgM and IgA |
Antibody isotypes associated with the SP | IgA SP = Secretory Protein |
Antibody isotype with longest half life | IgG (26 days compared with 5 for IgM, the next longest) |
Antibody isotype which prevents bacterial/viral attachment to mucous membranes | IgA |
Antibody isotype found in secretions | IgA |
Antibody isotype which mediates type I hypersensitivity | IgE |
How does IgE cause an allergic response? | Type I hypersensitivity 1. IgE binds to basophils or mast cells 2. IgE binds antigen 3. These cells release histamine and leukotrienes. |
Which cells have receptors for IgE? | 1. mast cells 2. basophils 3. eosinophils 4. monocytes/macrophages 5. platelets |
Antibody isotype which mediates immunity to worms | IgE |
Least abundant antibody isotype | IgE |
Define allotype | An individual's allele coding for the constant portions of the antibody's heavy chains. |
Define isotype | Specific type of chain in an antibody. Heavy isotypes: alpha, gamma, delta, epsilon, mu Light isotypes: kappa, lambda |
Define idiotype | antibodies of one idiotype share structure of their variable region and thus, antigen binding specificity. |
Cytokine effects: Interleukin 3 | Supports the growth and differentiation of bone marrow stem cells (similar to GM-CSF). Most important during early growth. Mnemonic for first 5 interleukins: Hot T-bone stEAk. bone, as in bone development |
What releases: Interleukin 3 | T cells (emphasis on activated T cells) and thymic epithelial cells |
Cytokine effects: Interleukin 6 | 1. Differentiation and growth of B cells and T cells 2. Systemic effects (Acute Phase Response and Fever) 3. Stimulates Ig production |
What releases: Interleukin 4 | Th2 cells |
Cytokine effects: Interleukin 8 | 1. Major neutrophil chemotactic and adhesion factor 2. Angiogenesis 3. High levels associated with schizophrenia |
What releases: Interleukin 8 | 1. Monocytes 2. Endothelial cells 3. Fibroblasts |
Cytokine effects: Interleukin 12 | 1. Promotes differentiation of Th cells into Th1 2. Activates NK cells |
What releases: Interleukin 12 | Professional Antigen Presenting Cells: 1. Dendritic cells 2. Macrophages 3. B cells |