Help
Options
Didn't know it?
click below
click below
Knew it?
click below
click below
Don't Know
Remaining cards (0)
Know
retry
shuffle
restart
0:00
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.
Normal Size Small Size show me how
Normal Size Small Size show me how
USMLE
Immuno - ILs/HLA/Abs
| Question | Answer |
|---|---|
| anti-nuclear | SLE & host of other autoimmune Dzs |
| anti-dsDNA, anti-Smith | specific for SLE |
| antihistone | drug-induce lupus (hydralazine, INH, procainamide, phenytoin) |
| anti-centromere | scleroderma (CREST, limited cutaneous, pumonary HTN) |
| anti-Scl-70 | scleroderma, diffuse |
| anti-IgG | Rheumatoid arthritis (anti-IgG = "Rheumatoid Factor") |
| antimitochondrial | primary biliary cirrhosis |
| antigliadin | celiac dz |
| anti-basement membrane | Goodpasture's |
| anti-epithelial cell | pemphigus vulgaris (desmoglein 3) |
| antimicrosomal | Hashimoto thyroiditis |
| Anti-Jo-1 | polymyositis, dermatomyositis |
| anti-neutrophil (C-ANCA, P-ANCA) | vasculitis |
| HLA-B27 | psoriasis, ankylosing Spondylitis, inflammatory bowel Dz, Reiter's |
| HLA-B8 | Graves' dz, celiac sprue |
| HLA-DR2 | MS, hay fever, SLE, Goodpasture's |
| HLA-DR3 | diabetes mellitus type 1 |
| HLA-DR4 | RA, diabetes mellitus type 1 |
| HLA-DR5 | pernicious anemia (which -> B12 defiency), Hashimoto thyroiditis |
| HLA-DR7 | steroid responsive nephrotic syndrome |
| Name the cytokine:secreted by macrophages, stimulates just about everything, endogenous pyrogen | IL-1 |
| which cytokine stimulates growth of helper and cytotoxic T cells | IL-2 |
| which cytokine supports growth and differentiation of BM stem cells | IL-3 (secreted by activated T cells) |
| which cytokine promotes growth of B cells and enhances class switching of IgE, IgG? | IL-4 |
| which cytokine enhances class switching of IgA? | IL-5 (also promotes differentiation of B cells, stimulates production and activation of eosinophils) |
| which cytokine stimulates activation and production of eosinophils? | IL-5 |
| which cytokine stimulates production of acute phase reactants and immunoglobulins? | IL-6 |
| which interleukin is one of the MAJOR chemotactic factors for PMNs? | IL-8 (also, C5a) |
| which cytokine stimulates Th2 and inhibits Th1? | IL-10 (secreted by Th2 cells themselves) |
| which cytokine activates NK cells and Th1 cells? | IL-12 (secreted by macrophages, B cells) |
| who is the "anticytokine" that inhibits growth and activity of T cells, counteracts effects of inflammatory cytokines, and stimulates wound healing? | TGF-beta |
| which cytokine increases IL-2 receptor synthesis by Th cells, and increased B cell proliferation? | TNF-alpha (also attracts and activates PMNs, stimulates dendritic cell migration to lymph nodes) |
| which cytokine is NOT produced in Job's syndrome--> "cold" staph abscesses | gamma-IFN (secreted by Th1 cells, stimulates macrophages) |
| what are the 2 signals required for activation of helper T cells? | 1) foreign Ag on MHC II recognized by TCR on Th cell; 2) costim by B7-CD28 |
| what are the 2 signals required for activation of cytotoxic T cells | 1) endogenously synthesized proteins on MHC I recognized by TCR; 2) IL-2 from Th cell activates cytotoxic cell |
| cell surface proteins of Helper T cells | CD4, TCR, CD3, CD28, CD40L |
| cell surface proteins of Cytotoxic T cells | CD4, TCR, CD3 |
| cell surface proteins of B cells | IgM, B7, CD19, CD20, CD40, MHC II |
| cell surface proteins of Macrophages | MHC II, CD14, Receptors for Fc & C3b |
| cell surface proteins of Natural Killer (NK) cells | Receptors for MHC I, CD16, CD56 |
| cell surface proteins of all cells except mature RBC's (all nucleated cells) | MHC I |
Created by:
Asclepius
Popular USMLE sets