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USMLE

Brain Tumors

QuestionAnswer
This adult tumor crosses the Corpus Collosum, stains for GFAP, and has tumor cells bordering areas of necrosis and hemorrhage on Light microscopy Glioblastoma Multiforme (Grade IV Astrocytoma)
This adult tumor has concentric arranged calcifications, and arises from arachnoid cells external to the brain. Meningioma
This adult tumor is S-100 Positive, and commonly occurs in the cerebellar pontine angle, bilaterally in neurofibromatosis 2 (chromosome 22) Schwannoma
This adult tumor is often in the frontal lobes, and has round nuclei with clear cytoplasm that is often calcified. You may see a chicken wire capillary pattern Oligodendroma
This Adult Tumor is often prolactin secreting, causes bitemporal hemianopsia, what is its origin? Rathke's Pouch (its a pituitary adenoma)
This childhood tumor is well circumscribed and contains eosinophilic corkscrew fibers. Pilocytic Astrocytoma. Low grade
This childhood tumor is most often in the cerebellum, and contains rosettes or pervivascular pseudorosettes, and can cause hydrocephalus. It is a form of a primintive neuroectoderm tumor Medulloblastoma.
This tumor is often in the 4th ventricle, and has characteristic rod shaped basal ciliary bodies found near the nucleus, as well as pervascular pseudorosettes Ependyoma
This childhood tumor is often in the cerebllum, and contains foamy cells and is rich in vasculature. What chromomome is likely altered and what hematological finding will be present? Chromosome 3 - Von Hippel Lindau, and you will find polycythemia due to increased EPO. The tumor is a Hemangioblastoma
This childhood tumor also causes bitemporial hemianopsia, and has calcifications. What is it derived from? Rathke's pouch - Craniopharyngioma.
Top 5 Childhood brain tumors ordered by descending incidence 1.) Pilocytic (low grade) astrocytoma 2.) Medulloblastoma 3.) Ependymoma 4.) Hemangioma 5.) Craniopharyngioma
Top 5 Adult brain tumors ordered by descending incidence 1.) GBM (grade IV astrocytoma) 2.) Meningioma 3.) Schwannoma 4.) Oligodendroglioma 5.) Pituitary adenoma
Location of most childhood brain tumors infratentorial
Location of most adult brain tumors supratentorial
Half of all adult brain tumors are metastases
Trigger words: Spindle cells, whorled pattern, psammoma bodies Meningioma
Trigger words: Aything associated w/NF 2 Schwannoma
Trigger words: pseudopalisading, butterfly, GFAP stain Glioblastoma Multiforme
Trigger words: fried egg Oligodendroglioma
Trigger words: Rathke's pouch - adult tumor? Rathke's pouch - childhood tumor? Pituitary adenoma Craniopharyngioma
Trigger words: Foamy cells Hemangioblastoma
Created by: Asclepius