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USMLE

Rate Limiting Enzymes

QuestionAnswer
Glycolysis Phosphofructokinase-1
Pyruvate Metabolism Pyruvate dehydrogenase complex
TCA cycle Isocitrate dehydrogenase
Citric acid cycle Citrate synthase
Glycogenesis Glycogen synthase
Glycogenolysis Glycogen phosphorylase
Gluconeogenesis Phosphoenolpyruvate carboxykinase & Fructose 1,6-Biphosphotase
Hexose Monophosphate Shunt Glucose 6 phosphate dehydrogenase
Pentose phosphate Glucose-6-phosphate dehydrogenase
Cholesterol synthesis HMG-CoA reductase
Ketone body synthesis HMG-CoA lyase
Fatty acid synthesis Acetyl CoA carboxylase
b oxidation of fatty acids Carnitine acyl transferase [CPT-1]
Lipogenesis Acetyl-CoA-carboxylase
Phospholipid synthesis Cytidyltransferase
Sphingolipid synthesis 3 ketosphiganine synthase
Eicosanoid synthesis Phospholipase A2
Prostaglandin synthesis Phospholipase A2
Steroidogenesis CSCC (27 desmolase)
Heme synthesis Aminolevulinate synthase
Bilirubin metabolism Active transport into bile ducts
Bile acid synthesis Colesterol 7a hydroxylase
DNA synthesis Ribonucleotide reductase
Purine synthesis Glutamine Prp transferase
Pyrimidine synthesis Carbamoyl phosphate synthetase II
Urea cycle Carbamoyl phosphate synthetase I
Lipolysis Hormone sensitive lipase
Fructose metabolism Aldolase B
Galactose metabolism Galactose 1-Phosphate Uridyltransferase
Heme Synthesis ALA synthase
Heme catabolism UDP glucoronyl transferase
Triglyceride synthesis from fatty acids Glycerol 3-P Dehydrogenase
Created by: Asclepius
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