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Antimanics (Lithium)

Mr. D Pharmacology Final

Thioridazine Mellaril
Clonazapam Klonopin
Clozapine Clozaril
Risperidone Risperdal
Quetiapine Seroquel
Antimanics are used in the treatment of mania (mood disorders)
What will you see in mania? excitement, hyperactivity, elevation of mood, very talkative (possible hallucinations)
What is the most commonly used drug for the treatment of mania? Lithium
What is the most common mood stabilizer? Lithium
State board exams always ask at least ___ question regarding Lithium. 1
Does lithium speed up or slows down neuronal activity? Slows down brain activity.
Lithium is similar to sodium
Sodium is required for the conduction of nerve impulses
Lithium interferes with nerve conduction
Lithium's interference with nerve conduction has what affect on the individual? Calming
Lithium is used to treat Mania in BP1 and BP2
Sodium causes neurotransmitters to jump the synaptic cleft
Lithium can become toxic if over dose
Lithium increases the reuptake of norepinephrine and dopamine
How long does lithium take to work? 1 to 2 weeks
Therapeutic blood levels of lithium range from 0.5 to 1.5 mEq/L
Maintenance dosage for Lithium 900-1200mg
Lithium side effects Mild to Moderate: Nausea, Tremors, Increased thirst, Increased urination
Lithium toxicity causes heart and kidney damage
Lithium signs of overdose vomiting, diarrhea, drowsiness, loss of equilibrium, ringing in ears(tinnitus), excessive thirst, excessive urination(wetting pants)
Lithium drug interactions with Ibuprofen, Naproxen, Diuretics, SSRI antidressant
2nd best choice for mania mood stabilization anticonvulsants
Name anticonvulsants Depakote, Gabapentin, Carbamazepine, Lamotrigine, Topiramate, Oxcarbazepine, Tiagabine
3rd best choice for mania Propranolol
How do anticonvulsants work? They increase the inhibitory actions of GABA
Anticonvulsant side effects dizziness, drowsiness, fatigue, nausea, tremors, rash, and weight gain
Anticonvulsant side effects increase or decrease with time? side effects lessen with time
Should pregnant women take anticonvulsants? no
Anticonvulsants can cause problems with what organ over time? liver
Propranolol is a Non-selective Beta blocker
Propranolol can be used for anticipatory performance issues to calm down without sedation. Lowers blood pressure
Student used propranolol to pass physical agility test
Propranolol only given if pulse rate is above > 60 beats per minute
Propranolol only give if blood pressure is above > 90/60 blood pressure
Mood stabilizers ok to give for schizo affective disorder
Lithium works best when it is the primary medication because it does not mix well with other drugs (Ibuprofen, Naproxen, Diuretics, SSRI antidressant)
fluoxetine (Prozac) daily dosage 20-40 mg
Created by: Sanctus Verus
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