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Mr. D Pharmacolgy

Pharm Ch 13 for test on 6/27/2014

Diazepam Valium
Lorazepam Ativan
Trifluoperazine Stelazine
Chlorpromazine Thorazine
Thioridazine Melleril
Clonazepam Klonopin
Clozapine Clozaril
Risperidone Risperdal
Quetiapine Seroquel
Neuroleptic Antipsychotic
Antipsychotic Psychotropic
Typical 1st generation antipsychotics have been used since the 1950's
Typical 1st generation antipsychotics (mechanism of action) Blocks Dopamine only (and some Adrenergic receptors)
Typical 1st generation antipsychotics relieve what type of symptoms (+) positive symptoms of schizophrenia
Typical 1st generation antipsychotics (side effects) More side effects than atypical 2nd generation antipsychotics (EPS)
Typical 1st generation antipsychotics (addictiveness) More addicting than atypical 2nd generation antipsychotics
Typical 1st generation antipsychotics (current use) Not used as much anymore
Atypical 2nd generation antipsychotics been used since the 1990's
Atypical 2nd generation antipsychotics (mechanism of action) Blocks dopamine and serotonin
Atypical 2nd generation antipsychotics (side effects) Major Weight Gain. Cause less side affects than typical 1st generation antipsychotics.
Atypical 2nd generation antipsychotics (addictiveness) Less addicting than 1st generation antipsychotics
Atypical 2nd generation antipsychotics (current use) Frequently used
Typical 1st generation med classes Phenothiazines and Butyrophenones
Phenothiazine drugs Clozapine, Thioridazine, Trifluoperazine
Butyrophenones drug Haloperidol
Phenothiazines have strong (AC) anticholinergic effects and (AAB) alpha-adrenergic-blocking effects
Phenothiazines block ACH
AC effects caused by phenothiazines Lowered Parasympathetic Affect: dry mouth, constipation, blurred vision, hypertension, increased pulse rate
Alpha adrenergic blocking causes hypotension
Anticholinergic mimics sympathetic response
Will Mr. D try to mix up drug name with drug class? Yes
What is the most important page in chapter 13 according to Mr. D 177, table 13:1
Clozapine side effects Impaction(worse than constipation), agranulocytosis
Mr. D say Clozapine is an all or nothing drug When it works its awesome, when not working no good.
Clozapine is used as a last resort
Clozapine using patients need labs(WBC), monitor weight, high fiber, and exercise
An antianxiety drug is considered a Benzodiazepine
Name 4 antianxiety (Benzodiazepine) drugs Lorezepam, Clonazepam, Alprazolam, and Diazepam(#1)
Invega drug class atypical 2nd generation
Which neurotransmitters are blocked by Invega? dopamine and serotonin
Extrapyramidal Symptoms (EPS) Dystonic reactions, Akathisia, and Parkinsonism
Dystonic Reactions muscle spasms, twitching, facial grimacing(torticollis)
Akathisia restlessness, constant body movement
Psuedo-Parkinsonism shuffling gate
Akinesia Not EPS, no movement
EPS drugs Benztropine(1st choice) and Trihexyphenidle(2nd choice)
Benztropine and Trihexyphenidle (drug class) Anticholinergic (Block ACH)
EPS is caused by blocking dopamine receptors in the basal ganglia
Dopamine and ACH should always be balanced
Psychotropic meds lower dopamine levels to treat psychosis. If Dopamine levels are lowered than ACH levels should also be lowered
Elderly people already have low levels of ACH
Tardive Dyskinesia Caused by long term use of antipsychotics. More common with 1st gen meds. Happens when going off med. Only way to stop it is to go back on medication. Permanently Irreversible. Involuntary movements of the tongue, jaw, lips, and extremities.
Neuroleptic Malignant Syndrome Fatal. Not dose related. Sx: diaphoresis, confusion, ANS instability, catatonia, elevated CPK, unstable blood pressure, and fatigue.
Treatment for NMS Stop medication immediately. Do not replace with another med.
If I block ACH which division of the ANS is being inhibited? Parasympathetic
If I block ACH what will happen to blood pressure? increased blood pressure
If I block ACH what will happen to pulse rate? increased pulse
Benztropine has the following side effects: hypertension, tachycardia, decrease secretions, decreased peristalsis
Benztropine leads to hypotension. True or False False
Trihexyphenidyl and Benztropine belong in the same family. True or Fasle True
Benztropine has a high potency
Increased triglycerides, weight gain, and diabetes are adverse effects associated with atypical drugs
What are the main goals of antipsychotic drug therapy? block the D2 receptor and decrease Serotonin
Select the adverse effects of atypical antipsychotics. postural hypotension and weight gain
What is the relationship between dopamine and ACH in terms of motor movement? If Dopamine low and ACH high it will result in: tremors
Created by: Sanctus Verus