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Patho Ch7 PopQuiz
| Question | Answer |
|---|---|
| True or false? Granulocytes are the shortest-surviving formed element in blood, surviving four days. | True |
| True or false? Leukocytes include monocytes, erythrocytes, and granulocytes. | False: Leukocytes are monocytes, lymphocytes, and granulocytes. |
| What do myeloid progenitor cells give rise to? Lymphoid progenitor cells? | Myeloid progenitor cells give rise to granulocytes, monocytes, erythrocytes, and megakaryocytes. Lymphoid progenitor cells give rise to lymphocytes. |
| what causes erythropoietin to be released? | Low oxygen levels detected by the kidneys |
| how long does a red blood cell live? | 120 days |
| what is the equation for calculating mean cell volume (MCV)? | Hct × 10/RBC |
| How would the MCHC change if hemoglobin production were decreased? | it would decrease |
| T/F? In sickle cell anemia, defective hemoglobin causes cells to sickle, clogging capillaries and impairing blood flow. | True |
| t/f? Intrinsic factor is secreted by the gastric mucosa | true |
| t/f? aplastic anemia causes death by hemorrhage or infection | true |
| in iron deficiency anemia, what happens to ferritin, iron, transferrin and iron binding capacity? | Serum iron and ferritin are low, while iron binding capacity and transferrin are increased. |
| Defective hemyglobin synthesis is a characteristic of what type of disease? | hemoglobinopathies |
| a patient's rbcs are seen to lyse when placed in a hypotonic saline. What hereditary deficiency might you diagnose him with? | hereditary spherocytosis |
| Iron deficiency anemia in older adults indicates what disease process until proven otherwise? | GI bleed, most likely secondary to GI cancer |
| a patient has surgical removal of part of his colon because of ulcerative colitis. Is he expected to have pernicious anemia after surgery? | no |
| t/f? dehydration causes relative polycythemia | true |
| t/f? patients with stress polycythemia have an increase in the absolute red cell mass | false |
| low erythropoietin in a setting of elevated rbc count is consistent with a diagnosis of | polycythemia vera |
| t/f? a left shift is the release of immature granulocytes from bone marrow into peripheral blood, and occurs only during an acute infection. | False: it does not occur with infection but may also occur in malignancy. |
| what are the two types of agranulocytosis? | dose related and idiosyncratic |
| If there is no infection, enlarged lymph nodes are worrysome for | malignancy |
| t/f? acute leukemia often presents as infection or hemorrhage | true |
| t/f? plasma cell proliferations are myeloid neoplasm. | false: they are lymphoid |
| t/f? lymphomas and leukemias are categorized by the WHO based on cell types and not genetic defects | False: genetic defects are important in classification |
| What are the two major groups of bone marrow malignancy? | myeloid and lympoid |
| what is the difference between leukemia and lymphoma? | in leukemia, the cells are present throughout the bone marrow and peripheral blood. In lymphoma, malignant cells occur as nodular masses in lymph nodes and other organs. |
| t/f? more than 90% of CMS patients survive after treatment | true |
| t/f? extramedullary hematopoiesis causes deformation of rbcs | true |
| a patient presents to the clinic complaining of shortness of breath, nosebleeds, and recurrent sinus infections. His WBC count is >100,000 and a genetic study reveals the 9;22 translocation. What is the treatment of choice? | Gleevec, imatinib |
| Name the myeloproliferative disorders and the cell precursor they affect | CML - myeloid/ WBCs, PV - erythrocytes/ ET-megakaryocytes, MF-myeloid cells |
| AML accounts for _% of acute leukemias | 70% |
| what symptoms commonly characterize leukemias and myelodysplastic syndromes? | anemia, infection and hemorrhage |
| which malignancy leads to too many red blood cells? Platelets? | polycythemia vera, malignant thrombocythemia |
| t/f? small cell lymphocytic lymphoma is very aggressive | true |
| t/f? nodular sclerosis type is the most common type of Hodgkin lymphoma | true |
| t/f? bence-jones proteins can be detected in a sample of blood | False: urine |
| a microscopic pattern on a lymph node biopsy resembling normal lymphoid follicles is characteristic of which lymphoma? | follicular lymphoma |
| a patient is found to have an elevated wbc count, Bence-jones proteins in her urine, and "punched" out lesions n an x-ray of the spine. what will protein electrophoresis reveal? | monoclonal gammopathy |
| the major groups of lymphomas are | Hodgkin lymphoma and non-hodgkin lymphoma |
| what do blood samples from patients with multiple myeloma and waldenstrom macroglobulinemia have in common? | increased blood immunoglobulins |
| which lymphoma has a better prognosis, follicular or diffuse? | follicular |
| for which lymphoma is chemotherapy more effective at killing turmor cells, follicular or diffuse. | diffuse, due to high mitotic rate |
| define hyperplenism | overactivity of the spleen that consumes more than the normal amt of wbcs, rbcs, or platelets |
| thymic hyperplasia and thymoma are associated with what autoimmune disease? | myasthenia gravis |
| After removal of the spleen (or auto infarction in sickle cell anemia), the patien is susceptible to what infections? | pneumococcus, meningococcus, and H. influenza |
| how can these infections be prevented? (pneumococcus, meningococcus, H. influenza) | vaccinations |
Created by:
tangerina
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