Busy. Please wait.
or

show password
Forgot Password?

Don't have an account?  Sign up 
or

Username is available taken
show password

why


Make sure to remember your password. If you forget it there is no way for StudyStack to send you a reset link. You would need to create a new account.
We do not share your email address with others. It is only used to allow you to reset your password. For details read our Privacy Policy and Terms of Service.


Already a StudyStack user? Log In

Reset Password
Enter the associated with your account, and we'll email you a link to reset your password.

Remove ads
Don't know
Know
remaining cards
Save
0:01
To flip the current card, click it or press the Spacebar key.  To move the current card to one of the three colored boxes, click on the box.  You may also press the UP ARROW key to move the card to the "Know" box, the DOWN ARROW key to move the card to the "Don't know" box, or the RIGHT ARROW key to move the card to the Remaining box.  You may also click on the card displayed in any of the three boxes to bring that card back to the center.

Pass complete!

"Know" box contains:
Time elapsed:
Retries:
restart all cards




share
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.

  Normal Size     Small Size show me how

Renal

Nephrotic / Nephritic syndromes

QuestionAnswer
Poststreptococcal glomerulonephritis NEPHRITIC- most common type of postinfections GN; usually follows group A strep infection of the skin and pharynx LM: glomeruli enlarged and hypercellurlar, neutrophils, "lumpy bumpy"; EM subepithelial humps; IF granular pattern; ICs activate complement p
Rapid Progressive (crescentric) glomerulonephritis NEPHRITIC - rapid loss of renal function progresses to acute renal failure; LM and IF; may or may not be associated with crescent formation (# of crescents is what determines prognosis) Associated with goodpastures, microscopic polyarteritis (p-anca) and
Membranoproliferative glomerulonephritis [diffuse proliferative GN] NEPHRITIC -subendothelial IC deposits with granular IF; EM subendothelial humps "tram tracks"; DNA-anti DNA ICs activate classical complement pathway; common cause of death is SLE, "wire looping"
IgA glomerulonephropathy (Bergers disease) Most common GN almost equal incident of nephritic or neprhotic presentation; Affects children and adults, often post infectious; increased mucosal synthesis and decreased clearance of IgA; increased serum IgA; Mesangial IgA IC deposits within granular. Pr
Alport syndrom split basement membrane; collagen IV mutation; nerve deafness and ocular disorders
Nephritic syndrome hypertension [due to salt retention] periorbital puffiness due to salt retention oliguria (<400 ml urine/day) due to decrease in GFR from inflamed glomeruli hematuria-dysmorphic RBC with irregular membranes, neutrophils in sediment RBC casts are KEY
Nephrotic syndromes Key finding is proteinuria greater than 3.5 g/24hrs generalized pitting edema and acites due to hypoalbuminemia, and spontanteous peritonitis (strep pnemo); hypertension in some types; hypercoaguable states due to loss of antithrombin III, hypercholester
Membranous glomerulonephritis NEPHROTIC:MCC of nephritic syndrome in adults; Drugs captopril; infx with HBV, plasmodium malaria, syphillis; Malignancy: carcinomas non-hodkins lymphoma; Autoimmune disease; SLE LM: diffues thickening of memebranes EM: silver stain show spike and dome
Minimal change disease NEPHROTIC:negative IF, EM shows fusion of podocytes and no deposits; T cell cytokines cause the GBM to lose its negative charge; selective proteinuria (albumin and globins), often preceeded by respiratory infxn or routine immunization; structurally normal
Focal segmental glomerular sclerosis NEPHROTIC:Primary of secondary causes disease secondary cause is HIV and IV heroin use negative IF; EM focal damage of visceral epithelial cells LM: segmental sclerosis and hyalinosis seen in african americans
Diabetic nephropathy LM : kimmelston wilson "wire loop" lesions, basememnt memebrane thickening;nodular glomerular changes
Amyloidosis IF congo red stain apple green bifringence; Associated with Multiple myeloma, chronic conditions, TB rheumatic arthritis
Created by: Roshani