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Pharm - Reactions

Common Drug Reactions from First Aid 2013

QuestionAnswer
Coronary vasospasm Cocaine, sumatriptan, ergot alkaloids
Cutaneous flushing Vancomycin, Adenosine, Niacin, Ca-ch blockers (VANC)
Dilated cardiomyopathy Doxorubicin, daunorubicin
Torsades de pointes Class III AA's (sotalol) Class IA AA's (quinidine)
Agranulocytosis Clozapine, Carbamazepine, Colchicine, Propylthiouracil, Methimazole, Dapsone
Aplastic Anemia Chloramphenicol, benzene, NSAIDS, propylthiouracil, methimazole
Hemolytic anemia (direct Coombs-positive) Methyldopa, penicillin
Gray Baby Syndrome Chloramphenicol
Hemolysis in G6PDH-def patients INH, Sulfa drugs, Nitro drugs, Primaquine, Aspirin, Ibuprofen
Megaloblastic anemia Phenytoin, Methotrexate, Sulfa drugs
Thrombosis OCP's + smoking
Cough ACE-inhibitors, use ARBs instead
Pulmonary fibrosis Bleomycin, Amiodarone, Busulfan
Acute cholestatic hepatitis with jaundice Erythromycin
Hepatic necrosis Halothane, Amanita phalloides, Valproate, Acetaminophen
Hepatitis INH (nerves and hepatocytes)
Pseudomembranous colitis Clindamycin, ampicillin
Adrenal insufficiency Glucocorticoid withdrawal without weaning
Gynecomastia Some Drugs Create Awkward Knockers: Spironolactone Digitalis Cimetidine Alcohol Ketoconazole
Hot flashes Tamoxifen, clomiphene
Hyperglycemia Niacin, Tacrolimus, protease inhibitors, HCTZ, corticosteroids
Hypothyroidism Lithium, amiodarone, sulfonamides
Fat redistribution Glucocorticoids, protease inhibitors
Gingival hyperplasia Phenytoin, verapamil
Gout Furosemide, thiazides, niacin, clyclosporine
Myopathies Fibrates, niacin, colchicine, hydroxychloroquine, interferon-a, penicillamine, statins, glucocorticoids Fish N CHIPS Give you myopathies!
Osteoporosis Steroids, heparin
Photosensitivity Sulfonamides, Amiodarone, Tetracycline
SJS Penicillin, ethosuximide, carbamazepine, sulfa drugs, lamotrigine, allopurinol, phenytoin, phenobarbital
SLE-like syndrome Hydralazine, INH, Procainamide, Phenytoin
Teeth staining Tetracyclines
Tendonitis, cartilage damage Fluoroquinolones
Diabetes insipidus Lithium, demeclocycline
Fanconi syndrome Expired tetracycline
Hemorrhagic cystitis Cyclophosphamide, ifosfamide Give Mesna
Interstitial nephritis beta-lactam Abx, NSAIDs, diuretics, Rifampin, sulfonamides
SIADH carbamazepine, cyclophosphamide
Cinchonism Quinidine, quinine
Parkinsonism Antipsychotics, reserpine, metoclopramide
Seizures INH, Bupropion, Imipenem/cilastatin, Tramadol, Enflurane, Metoclopramide
Tardive dyskinesia Antipsychotics
Anti-muscarinic effects Atropine, TCAs, H1-blockers, neuroleptics
Disulfiram-like reaction Metronidazole, cephalosporins, procarbazine, 1st-generation sulfonylureas (for DM)
Nephro/Oto-toxicity Aminoglycosides, vancomycin, Loop diuretics, Cisplatin
P-450 upregulators Momma Barb Steals Phenytoin and Refuses Greasy Carbs Chronically: Modafinil Barbiturates St. John's wort Phenytoin Rifampin Griseofulvin Carbamazepine Chronic alcohol use
P-450 inhibitors MAGIC RACKS in GQ: Macrolides Amiodarone Grapefruit juice INH Cimetidine Ritonavir Acute alcohol abuse Ciprofloxacin Ketoconazole Sulfas Gemfibrozil Quinidine
Sulfa drugs Probenecid Furosemide Acetazolamide Celecoxib Thiazides Sulfa Abx Sulfasalazine Sulfonylureas
Common sulfa drug reactions Fever, UTIs, pruritic rash, SJS, hemolytic , TCP agranulocytosis, urticaria
Created by: wmwebb89