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Pharm - Immunology

Immunology Pharmacology from First Aid 2013

QuestionAnswer
Cyclosporine: MOA, Use, Tox MOA: bind to cyclophilins and inactivates calcineurin, inhibiting IL-2/T-Cell diff Use: prevent organ rejection after Tx Tox: nephrotox, HTN, hyper glyc/lipidemia, tremor, gingival hyperplasia, hirsutism
Tacrolimus (FK-506): MOA, Use, Tox MOA: binds to FK and inactivates calcineurin, inhibiting IL-2/T-Cell diff Use: potent immunosuppressor, organ Tx Tox: like cyclosporine; no gingiva, hirsutism
What is sirolimus? What are its uses and toxicities? Rapamycin, mTOR inhibitor Use: kidney Tx, with others Tox: hyperlipidemia, other cytopenias
Azathioprine: MOA, Use, Tox MOA: 6-MP, toxic to proliferating lymphocytes Use: kidney Tx, A/I glomerulonephritis or AIHA Tox: BM suppression, toxic with allopurinol
Muromonab-CD3 (OKT3): MOA, Use, Tox MOA: Ab vs. CD3 on T-Cells Use: after kidney Tx Tox: cytokine release syndrome, H-S rxn
Infliximab,: MOA and use MOA: anti TNFa Use: Anti-PAIR (HLA-B27) diseases
What is adalimumab? It's an anti-TNFa ab like infliximab.
When do you use alpha interferon? Hep B and C, Kaposi's sarcoma, leukemias, malignant melanoma
When do you use beta interferon? Multiple sclerosis
When do you use gamma interferon? Chronic granulomatous disease
Created by: wmwebb89
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