Save
Busy. Please wait.
or

show password
Forgot Password?

Don't have an account?  Sign up 
or

Username is available taken
show password

why


Make sure to remember your password. If you forget it there is no way for StudyStack to send you a reset link. You would need to create a new account.
We do not share your email address with others. It is only used to allow you to reset your password. For details read our Privacy Policy and Terms of Service.


Already a StudyStack user? Log In

Reset Password
Enter the associated with your account, and we'll email you a link to reset your password.
focusNode
Didn't know it?
click below
 
Knew it?
click below
Don't know
Remaining cards (0)
Know
0:00
share
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.

  Normal Size     Small Size show me how

Pharm - Renal

Renal Pharmacology from First Aid 2013

QuestionAnswer
Mannitol: MOA, Use, Tox MOA: osmotic diuretic Use: drug O/D, elevated intra-ocular pressure Tox: pulmonary edema, dehydration C/I in CHF, duh
Acetazolamide: MOA, Use, Tox MOA: carbonic anhydrase inhibitor -> bicarb diuresis and decreased HCO3- Use: glaucoma, urine alkalinization, altitude sickness, pseudotumor cerebri Tox: hyperchloremic metablic acidosis, NH3+ toxicity, parasthesia
Name the two major Loop diuretics. Furosemide (sulfa version) Ethacrynic acid (non-sulfa alternative)
Furosemide: MOA, effects Inhibits Na/K/2Cl co-transport Stimulates vaso-dilatory PGE at aff art. Wastes Ca, Mg paracellularly, K-wasting
Furosemide: Toxicities OH DANG! Ototoxicity, Hypokalemia, Dehydration, Allergy (Sulfa), Nephritis (Interstitial), Gout
Hydrochlorothiazide: MOA, effects Inhibits NaCl reabsorption in the early DCT and decreases Ca2+ secretion (Ca-saving). Wastes K and H+ (--> metabolic alkalosis).
Hydrochlorothiazide: Toxicities HyperGLUC: glycemia lipidemia uricemia calcemia
Name some potassium-sparing diuretics. Spironolactone, Triamterene, Amiloride
Spironolactone: MOA, side effects Competitive aldosterone receptor antagonist. Tox: hyperkalemia SFX: anti-androgenic, gynecomastia
Amiloride: MOA, Tox Blocks the Na channels in the CCT. Tox: hyperkalemia
Explain the mechanism of contraction alkalosis. Volume contraction -> inc ATII -> inc Na/H+ exchange in the PCT -> inc bicarb reabsorption
Explain how Loop and Thiazide diuretics cause metabolic alkalosis. (1) K+ loss leads to K+ exiting the cells in exchange for H+ entering into the cells. (2) In a low K-state, H+ (rather than K+) is exchanged for Na+ in the CCT, leading to alkalosis and paradoxical aciduria. (3) Contraction alkalosis.
ACE inhibitors: naming, MOA Nom: "-opril" MOA: Inhibit ACE -> dec ATII -> dec GFR by preventing constriction of eff art -> inc renin.
ACE inhibitors: Toxicities Cough (ACE breaks down bradykinin), angioedema, teratogen, inc Cr (dec GFR), Hyperkalemia, HypoTN
ACE Inhibitors: indications and contraindications Use: HTN, CHF, proteinuria, diabetic renal disease, prevent heart remodeling in HF C/I: avoid in renal artery stenosis, b/c dec in GFR will further exacerbate -> RF.
ARBs: naming, MOA, Use, Tox Nom: "-artan", e.g. losartan MOA: ATII receptor blockers Use: HTN, CHF, just like ACE-Is Tox: same mortality benefits, but no side effect of cough!
Created by: wmwebb89
 

 



Voices

Use these flashcards to help memorize information. Look at the large card and try to recall what is on the other side. Then click the card to flip it. If you knew the answer, click the green Know box. Otherwise, click the red Don't know box.

When you've placed seven or more cards in the Don't know box, click "retry" to try those cards again.

If you've accidentally put the card in the wrong box, just click on the card to take it out of the box.

You can also use your keyboard to move the cards as follows:

If you are logged in to your account, this website will remember which cards you know and don't know so that they are in the same box the next time you log in.

When you need a break, try one of the other activities listed below the flashcards like Matching, Snowman, or Hungry Bug. Although it may feel like you're playing a game, your brain is still making more connections with the information to help you out.

To see how well you know the information, try the Quiz or Test activity.

Pass complete!

"Know" box contains:
Time elapsed:
Retries:
restart all cards