Save
Busy. Please wait.
Log in with Clever
or
show password
Forgot Password?
Don't have an account?  Sign up 
Sign up using Clever
or
Username is available taken
show password


Make sure to remember your password. If you forget it there is no way for StudyStack to send you a reset link. You would need to create a new account. Your email address is only used to allow you to reset your password. See our Privacy Policy and Terms of Service.

Already a StudyStack user? Log In

Reset Password
Enter the associated with your account, and we'll email you a link to reset your password.
focusNode
Didn't know it?
click below
 
Knew it?
click below
Don't Know
Remaining cards (0)
Know
0:00
edit
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.

  Normal Size     Small Size show me how

Pharm - Gastro

Gastrointestinal Pharmacology from First Aid 2013

QuestionAnswer
H2 Blockers: Naming, MOA, Use, Tox Nom: Cimetidine, "-idine" MOA: rev block histmaine receptors decrease H+ secretion by parietal cells Use: Peptic ulcer, gastritis, reflux Tox: CYP450 interactions, anti-androgenic
PPI's: Naming, MOA, Use, Tox Nom: Omeprazole, "-azole" MOA: irrev block H+/K+ ATP-ase at parietal cc Use: ucler, gastritis, reflux, ZES Tox: Risk of C.diff infxn, pneumonias, hip fractures and dec Mg2+ with long use
Bismuth, sucralfate: MOA and Use Creates a physical webbing-mesh to protect an ulcer and increases the mucous barrier. Use with ETEC and ulcer healing.
Misoprostol: MOA, Use, Tox MOA: PGE1 analog, inc mucous, dec acid Use: Prevent NSAID-induced ulcers also maintains PDA and ripens cervix Tox: Diarrhea and abortive agent
What is Octreotide? How should you use it? What are its GI toxicities? Somatostatin analog. Used for: Acromegaly, varices, VIP-oma, carcinoid Tox: Nausea, cramps, steatorrhea
Name three mineral-based antacids. What side effects are common to all? Mg hydroxide Al hydroxide Ca-carbonate All cause hypokalemia and poor absorption.
Side effects of Mg hydroxide? MG = "must go" to the bathroom! Diarrhea.
Side effects of Al hydroxide? Aluminum = "minimum" amount of feces -> constipation. Also, hypophosphatemia.
Side effects of Calcium carbonate antacid? Hypercalcemia. Can chelate and reduce the effictiveness of other drugs (e.g., tetracycline).
Name some osmotic laxatives? How might they be misused? Mg hydroxide, Mg citrate, Lactulose Draw out water via osmotic load. Abused by bulimics.
In addition to functioning as a laxative, lactulose also treats what? Hyperammonemia. It promotes NH4+ excretion.
Infliximab: MOA, Use, Tox MOA: monoclonal Ab to TNF-alpha Use: Crohn's, UC, RA Tox: infection, reactivated TB, oligospermia
Sulfasalazine (5-ASA): MOA, Use, Tox MOA: ASA(Aspirin) + sulfapyridine(antibact) Use: Ulcerative colitis Tox: malaise, nausea, sulfa tox, oligospermia
Ondansetron: MOA, Use, Tox MOA: 5-HT antagonist at area postrema Use: anti-emetic, e.g., for chemo Tox: headache, constipation
Metoclopramide: MOA, Use, Tox MOA: D2 receptor antagonist, inc LES tone Use: gastroparesis post surgery, anti-emetic Tox: Parkinsonism, C/I with obstruction
Created by: wmwebb89
Popular USMLE sets

 

 



Voices

Use these flashcards to help memorize information. Look at the large card and try to recall what is on the other side. Then click the card to flip it. If you knew the answer, click the green Know box. Otherwise, click the red Don't know box.

When you've placed seven or more cards in the Don't know box, click "retry" to try those cards again.

If you've accidentally put the card in the wrong box, just click on the card to take it out of the box.

You can also use your keyboard to move the cards as follows:

If you are logged in to your account, this website will remember which cards you know and don't know so that they are in the same box the next time you log in.

When you need a break, try one of the other activities listed below the flashcards like Matching, Snowman, or Hungry Bug. Although it may feel like you're playing a game, your brain is still making more connections with the information to help you out.

To see how well you know the information, try the Quiz or Test activity.

Pass complete!
"Know" box contains:
Time elapsed:
Retries:
restart all cards