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block #3 pharm.
| Thrombin Inhibitors | Heparin, Fondaprinux (LMW), Warfarin |
| Platelet Inhibitors | Aspirin, Clopidogrel |
| Fribrinolytics | Streptokinase Coagulants/Antidotes: Protamine Sulfate, Vitamin K1 |
| Hemostasis | process that stops blood vessels form leaking after being damaged |
| Thrombosis | formation of a blood clot inside a blood vessel |
| A clot is produced in three phases: | 1. vascular phase 2. platelet phase 3. coagulation phase |
| Strategies to prevent thrombosis: | 1. inhibit thrombin 2. inhibit platelet function 3. inhibit fibrin formation |
| Arthralgia | joint pain |
| Myalgia | pain associated with muscle injury |
| Urticaria | hives |
| Emesis | vomiting |
| Erythema | redness of the skin |
| Dysphoria | the opposite of euphoria |
| Salicylism | condition in which toxic doses of salicylates result in nausea, tinnitus, and delerium |
| Arthritis | inflammation of the joints |
| Hyperemia | increased blood flow to a body part |
| Allergen | substance capable of producing an allergic reaction |
| Nonselective | interacts with any subtype receptor |
| Chronic Bronchitis | a respiratory condition caused by chronic irritation that increases secretion of mucus and causes degeneration of the respiratory lining |
| COPD | chronic obstructive pulmonary disease |
| Bronchodilator | a drug that relaxes bronchial smooth muscle and dilates the lower respiratory passages |
| Asthma | characterized by shortness of breath and wheezing |
| Oliguria | production of only small amount of urine |
| ADH | antidiuretic hormone |
| Dysmenorrhea | painful menstruation |
| Petechia | small area of the skin or mucus membrane that is discolored because of localized hemorrhages |
| Emphysema | a disease in which patients have difficulty expelling air from the lungs; causes destruction of the walls of the alveoli |
| Rheumatic Fever | condition in which pain and inflammation of joints are accompanied by elevated body temperature |
| Wheal | firm, elevated swelling of the skin |
| Mucolytic | a drug that liquefies bronchial secretions |
| Anuria | production of no urine |
| Antigen | substance that stimulates an immune response |
| Excoriation | an abrasion of the epidermis |
| Histamine | chemical mediator released from mast cells |
| Phlegm | mucus |
| Analgesic | a substance that inhibits ones reaction to pain |
| H1 First Generation | -Diphenhydramine -Dimenhydranate -Chlorpheniramine |
| H1 Second Generation | -Loratadine -Desloratadine -Fexofenadine -Cetirizine |
| H2 | -Cimetidine -Ranitidine -Pepcid |
| Histamine is found...... | throughout the body in the MAST CELLS and basophils (white blood cells) |
| The largest concentration of mast cells are in the..... | lungs, the gastrointestinal (GI) tract, and the skin |
| H1: Smooth Muscle | -Bronchoconstriction -intestinal cramps and diarrhea -vasodilation |
| H1: Nervous System | -pain -itching |
| H2: Gastric Mucosa | -Gastric acid secretion |
| H2: Cardiac Muscle | -Stimulant effect |
| H3: Nervous System | -pain -itching |
| H4: Immune System | -Leukocytes (especially eosinophil) |
| Therapeutic use of H1 receptor antagonists: Type-1 hypersensitivity reactions | allergic rhinitis, sneezing, and itching of eyes |
| Therapeutic use of H1 receptor antagonists: Allergic dermatoses | can control itching associated with insect bites |
| Therapeutic use of H1 receptor antagonists: Antiemetic | prevention or treatment of nausea and vomiting (anti-muscarinic effect) NOT DURING PREGNANCY |
| Therapeutic use of H1 receptor antagonists: Parkinson's disease | reduction of tremors and muscle rigidity (anti-muscarinic effect) |
| Anemia: Antianemics | -Ferrous sulfate -Vitamin B12 -Folic acid -erythropoietin |
| Anemia: Antidotes | =Deferoxamine |