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TERATOGENIC
PHARM
Question | Answer |
---|---|
Antibiotics to avoid in PREGNANCY | SAFe Children Take Really Good Care S= Sulfonamides A= Aminoglycosides F= Fluoroquinolones C= Clarithromycin T= Tetracyclines R= Ribavirin (antiviral) G= Griseofulvin (antifungal) C= Chloramphenicol |
Discolored teeth, inhibition of bone growth | Tetracyclines |
Cartilage damage | Fluoroquinolones |
Kernicterus | Sulfonamides |
Ototoxicity (CN VIII) | Aminoglycosides |
¨Gray Baby¨ | Chloramphenicol |
Renal damage | ACE inhibitors |
Vaginal clear cell adenocarcinoma, Congenital Mullerian anomalies | Diethylstilbestrol (DES) |
Neural Tube defects | Folate antagonists |
Ebstein anomaly (atrialized right ventricle) | Lithium |
Fetal hydantoin syndrome: microcephaly, dysmorphic craniofacial features, hypoplastic nails and distal phalanges, cardiac defects, IUGR, mental retardation | Phenytoin |
Inhibition of maternal folate absorption= neural tube defects | Valproate |
Warfarin | 1.Bone deformities 2.Fetal hemorrhage 3.Abortion, 4.Ophthalmologic abnormalities |
Leading cause of birth defects and mental retardation | Maternal ALCOHOL abuse |
Abnormal fetal development and fetal addiction; placental abruption | Cocaine |
Congenital goiter or hypothyroidism (cretinism) | Iodine (lack or excess) |
Maternal diabetes | Caudal regression syndrome (anal atresia to sirenomelia), congenital heart defects, neural tube defects |
Microcephaly, holoprosencephaly, facial abnormalities (smooth philtrum, thin upper lip, palpebral fissures, hypertelorism), limb dislocation and heart defects | Fetal Alcohol syndrome |
Fetus is most susceptible during | 3rd-8th week (embryonic period- organogenesis) |
Before week 3 | All or none effect |
After week 8 | Growth and function affected |