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TERATOGENIC

PHARM

QuestionAnswer
Antibiotics to avoid in PREGNANCY SAFe Children Take Really Good Care S= Sulfonamides A= Aminoglycosides F= Fluoroquinolones C= Clarithromycin T= Tetracyclines R= Ribavirin (antiviral) G= Griseofulvin (antifungal) C= Chloramphenicol
Discolored teeth, inhibition of bone growth Tetracyclines
Cartilage damage Fluoroquinolones
Kernicterus Sulfonamides
Ototoxicity (CN VIII) Aminoglycosides
¨Gray Baby¨ Chloramphenicol
Renal damage ACE inhibitors
Vaginal clear cell adenocarcinoma, Congenital Mullerian anomalies Diethylstilbestrol (DES)
Neural Tube defects Folate antagonists
Ebstein anomaly (atrialized right ventricle) Lithium
Fetal hydantoin syndrome: microcephaly, dysmorphic craniofacial features, hypoplastic nails and distal phalanges, cardiac defects, IUGR, mental retardation Phenytoin
Inhibition of maternal folate absorption= neural tube defects Valproate
Warfarin 1.Bone deformities 2.Fetal hemorrhage 3.Abortion, 4.Ophthalmologic abnormalities
Leading cause of birth defects and mental retardation Maternal ALCOHOL abuse
Abnormal fetal development and fetal addiction; placental abruption Cocaine
Congenital goiter or hypothyroidism (cretinism) Iodine (lack or excess)
Maternal diabetes Caudal regression syndrome (anal atresia to sirenomelia), congenital heart defects, neural tube defects
Microcephaly, holoprosencephaly, facial abnormalities (smooth philtrum, thin upper lip, palpebral fissures, hypertelorism), limb dislocation and heart defects Fetal Alcohol syndrome
Fetus is most susceptible during 3rd-8th week (embryonic period- organogenesis)
Before week 3 All or none effect
After week 8 Growth and function affected
Created by: heidy39