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TERATOGENIC
PHARM
| Question | Answer |
|---|---|
| Antibiotics to avoid in PREGNANCY | SAFe Children Take Really Good Care S= Sulfonamides A= Aminoglycosides F= Fluoroquinolones C= Clarithromycin T= Tetracyclines R= Ribavirin (antiviral) G= Griseofulvin (antifungal) C= Chloramphenicol |
| Discolored teeth, inhibition of bone growth | Tetracyclines |
| Cartilage damage | Fluoroquinolones |
| Kernicterus | Sulfonamides |
| Ototoxicity (CN VIII) | Aminoglycosides |
| ¨Gray Baby¨ | Chloramphenicol |
| Renal damage | ACE inhibitors |
| Vaginal clear cell adenocarcinoma, Congenital Mullerian anomalies | Diethylstilbestrol (DES) |
| Neural Tube defects | Folate antagonists |
| Ebstein anomaly (atrialized right ventricle) | Lithium |
| Fetal hydantoin syndrome: microcephaly, dysmorphic craniofacial features, hypoplastic nails and distal phalanges, cardiac defects, IUGR, mental retardation | Phenytoin |
| Inhibition of maternal folate absorption= neural tube defects | Valproate |
| Warfarin | 1.Bone deformities 2.Fetal hemorrhage 3.Abortion, 4.Ophthalmologic abnormalities |
| Leading cause of birth defects and mental retardation | Maternal ALCOHOL abuse |
| Abnormal fetal development and fetal addiction; placental abruption | Cocaine |
| Congenital goiter or hypothyroidism (cretinism) | Iodine (lack or excess) |
| Maternal diabetes | Caudal regression syndrome (anal atresia to sirenomelia), congenital heart defects, neural tube defects |
| Microcephaly, holoprosencephaly, facial abnormalities (smooth philtrum, thin upper lip, palpebral fissures, hypertelorism), limb dislocation and heart defects | Fetal Alcohol syndrome |
| Fetus is most susceptible during | 3rd-8th week (embryonic period- organogenesis) |
| Before week 3 | All or none effect |
| After week 8 | Growth and function affected |
Created by:
heidy39