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Opportunistic fungai

Dimorphic yeast. Pseudohyphae and budding yeasts at 20ºc Germ tubes at 37ºC Candida Albicans
Aflatoxins associated with HCC Aflatoxin B1, Aspergillus fumigatus
Associated with asthma or CF; may cause Bronchiectasis and Eosinophilia, Increased IgE Aspergillus
Most common fungal meningitis of immunocompromised in US Cryptococcus neoformans
Found in soil, pigeon droppings. Acquired through inhalation with hematogenous dissemination to meninges. Cryptococcus neoformans
Culture on Sabouraud's agar. Stains with India ink. Cryptococcus neoformans
Latex agglutination test detects polysaccharide capsular antigen and is more specific. Cryptococcus neoformans
"Soap bubble" lesions in brain. Cryptococcus neoformans
Rhinocerebral, frontal lobe abscesses. Headache, facial pain, black necrotic eschar on face; may have cranial nerve involvement Mucor and Rhizopus spp.
Irregular, broad, nonseptate hyphae branching at wide angles Mucor
Septate hyphae that branch at 45º angle Aspergillus
Diffuse, bilateral CXR appearance. Pneumocystis jirovecii
Diagnosed by lung biopsy or lavage. Disc-shaped yeast forms on methenamine silver stain of lung tissue Pneumocystis jirovecii
Methenamine silver stain Pneumocystis jirovecii
Cigar-shaped budding yeast Sporothrix schenckii
Sporothrix schenckii treatment Potassium iodide
"rose gardener's" disease Sporothrix schenckii
Spores are traumatically introduced into the skin, typically by a thorn causes local pustule or ulcer with nodules along draining lymphatics (ascending lymphangitis). Sporothrix schenckii
When to start prophylaxis for Pneumocystis jirovecii CD4 drops < 200 cells/mm3 in HIV patients with Dapsone
Created by: heidy39



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