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Systemic mycoses

Macrophage filled with Histoplasma (smaller than RBC) Histoplasmosis
CXR: bilateral hilar adenopathy, hepatosplenomegaly in a young men that expended the weekend exploring caves down to the Ohio River valleys Histoplasmosis, Bat droppings
Culture 25ºC, Broad-base budding doubly refractive wall (same size as RBC), encapsulated Blastomycosis
Potassium Hydroxyde (KOH) sputum Blastomycosis
Spherule filled with endospores (much larger than RBC) Coccidioidomycosis (can cause Meningitis)
Systemic mycoses All can cause pneumonia and disseminate. All are caused by dimorphic fungi: cold (20°C) = mold; heat (37°C) = yeast. EXCEPTION: coccidioidomycosis, spherule (not yeast) Mimic TB (granuloma formation), unlike TB, no person-person transmission.
Systemic mycoses Treatment: fluconazole or itraconazole for local infection; amphotericin B for systemic infection.
Created by: heidy39



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