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Sleep patterns of depressed patients 1. Decreased slow-wave sleep 2. Decreased REM latency 3. Increased REM early in sleep cycle 4. Increased total REM sleep 5. Repeated nighttime awakenings 6. Early-morning awakening (important screening question)
Circadian rhythm suprachiasmatic nucleus (SCN) of hypothalamus.
Sleep terror disorder non-REM sleep (no memory of arousal)
Nightmares REM sleep (memory of a scary dream).
Excessive daytime sleepiness, nocturnal and narcoleptic sleep episodes, cataplexy, decreased orexin production in lateral hypothalamus Narcolepsy
HypnaGOgic hallucinations GOing to sleep
HypnoPOmpic hallucinations POst-sleep
Double-blinded Neither patient nor doctor knows whether the patient is in the treatment or control group
Case-control study Observational and retrospective Odds ratio What happened?
Cross-sectional study Observational and prospective or retrospective Disease prevalence What is happening?
retardation, self-mutilation, aggression, hyperuricemia, gout, choreoathetosis. Lesch-Nyhan syndrome; Defective purine salvage due to absence of HGPRT, excess uric acid. X-linked recessive.
One of the major causes of SCID. Autosomal recessive. Adenosine deaminase deficiency
Point mutations in DNA, severity of damage silent<< missense< nonsense< frameshift.
Alpha-amanitin (amatoxins) inhibits RNA polymerase II (halting mRNA synthesis)
Created by: heidy39



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